Atypical patterns of cerebral motor activation in autism: a functional magnetic resonance study

Biological Psychiatry
Ralph-Axel MüllerEric Courchesne

Abstract

Early neurodevelopmental pathogenesis in autism potentially affects emerging functional maps, but little imaging evidence is available. We studied eight male autistic and eight matched normal subjects, using functional magnetic resonance imaging during visually paced finger movement, compared to a control condition (visual stimulation in the absence of motor response). Groupwise analyses showed activation in contralateral perirolandic cortex, basal ganglia, and thalamus, bilateral supplementary motor area, and ipsilateral cerebellum for both groups. However, activations were less pronounced in the autism group. Direct group comparisons demonstrated greater activation in perirolandic and supplementary motor areas in the control group and greater activation (or reduced deactivation) in posterior and prefrontal cortices in the autism group. Intraindividual analyses further showed that strongest activations were consistently located along the contralateral central sulcus in control subjects but occurred in locations differing from individual to individual in the autism group. Our findings, though based on a rather small sample, suggest abnormal individual variability of functional maps and less distinct regional activation/deactiva...Continue Reading

References

Dec 15, 1992·Biological Psychiatry·J R HolttumN E Phillips
Mar 1, 1996·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·K J FristonR Turner
Sep 1, 1996·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·M BlinkenbergI Law
Mar 1, 1996·Journal of Child Neurology·R H HaasR Yeung-Courchesne
Apr 1, 1997·Development and Psychopathology·R Yeung-Courchesne, E Courchesne
Oct 1, 1997·Journal of Cognitive Neuroscience·G L ShulmanS E Petersen

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Citations

Apr 13, 2006·Journal of Autism and Developmental Disorders·Eva M JansiewiczStewart H Mostofsky
Apr 13, 2006·Journal of Autism and Developmental Disorders·George C WagnerAlycia K Halladay
Oct 19, 2006·Journal of Autism and Developmental Disorders·Natacha AkshoomoffRichard Haas
May 26, 2009·Journal of Autism and Developmental Disorders·Natasha NazaraliDigby Elliott
Feb 14, 2003·Current Neurology and Neuroscience Reports·Maria T Acosta, Phillip L Pearl
Mar 1, 2012·The Cerebellum·S Hossein FatemiJohn P Welsh
Mar 19, 2002·Physiology & Behavior·David KahnePatricia M Whitaker-Azmitia
Aug 15, 2002·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Heather CodyJoseph Piven
Jun 18, 2002·Brain Research. Cognitive Brain Research·Ralph Axel MüllerEric Courchesne
Oct 17, 2003·Brain Research. Cognitive Brain Research·Matthew K Belmonte, Deborah A Yurgelun-Todd
Apr 25, 2009·Brain : a Journal of Neurology·Stewart H MostofskyJames J Pekar
Jul 28, 2010·PloS One·Dezso NemethAgnes Vetro
Feb 6, 2014·Neuropsychology Review·Jose O MaximoRajesh K Kana
May 17, 2006·Proceedings of the National Academy of Sciences of the United States of America·Daniel P KennedyEric Courchesne
May 3, 2006·Journal of Autism and Developmental Disorders·Marco R HoeksmaHerman van Engeland
Dec 25, 2009·Neuroradiology·Judith S VerhoevenStefan Sunaert
Oct 5, 2007·Psychiatry Research·Yukari TakaraeJohn A Sweeney
Nov 26, 2015·Frontiers in Neuroscience·Anila M D'Mello, Catherine J Stoodley
Jan 30, 2004·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Deborah K Sokol, Mary Edwards-Brown
Dec 17, 2008·Annals of the New York Academy of Sciences·Ralph-Axel Müller
Mar 18, 2006·Developmental Medicine and Child Neurology·Nicole J RinehartKatherine A Johnson
Sep 4, 2015·Science China. Life Sciences·Matthew W Mosconi, John A Sweeney
Jul 14, 2010·Autism Research : Official Journal of the International Society for Autism Research·Oswald J N BloemenDeclan G M Murphy
Mar 16, 2012·Human Brain Mapping·Lisa B WilsonDonald C Rojas
Jan 28, 2003·Biological Psychiatry·Katherine D TsatsanisRobert T Schultz
Dec 4, 2004·Seminars in Pediatric Neurology·Maria T Acosta, Phillip L Pearl
Sep 1, 2004·Biological Psychiatry·Ralph-Axel MüllerEric Courchesne
Mar 8, 2005·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Lonnie ZwaigenbaumPeter Szatmari
Sep 2, 2006·Psychiatry Research·Antonio Y HardanNancy J Minshew
Jul 11, 2006·Brain Research·Akiko MizunoRalph-Axel Müller
Mar 17, 2004·Magnetic Resonance Imaging Clinics of North America·Chad Moritz, Victor Haughton
Jan 18, 2005·Biological Psychiatry·Ruth A Carper, Eric Courchesne
Feb 13, 2004·Journal of Child Psychology and Psychiatry, and Allied Disciplines·Fred R VolkmarAmi Klin
Nov 6, 2008·Developmental Psychobiology·Wanda M SnowTammy L Ivanco
Sep 9, 2015·Pediatric Radiology·Nolan R Altman, Byron Bernal
Sep 22, 2015·Frontiers in Neuroscience·Matthew W MosconiJohn A Sweeney
Jul 25, 2015·Journal of Clinical and Experimental Neuropsychology·Joana C CarmoCarlos N Filipe

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