Atypical pemphigus with immunoglobulin G autoantibodies against desmoglein 3 and desmocollin 3

The Journal of Dermatology
Koji KamiyaYoshiki Tokura

Abstract

In patients with pemphigus vulgaris (PV), pathogenic immunoglobulin (Ig)G antibodies are most commonly directed against desmoglein 3 (Dsg3). It has recently been reported, however, that IgG anti-desmocollin 3 (Dsc3) antibodies are detected in some cases of pemphigus with or without IgG anti-Dsg3 antibodies. We present a case of pemphigus with IgG antibodies against Dsg3 and Dsc3. Subsequent studies showed that the cell surface distribution pattern of Dsc3 but not Dsg3 was altered, suggesting that suprabasal acantholytic blisters were induced by IgG anti-Dsc3 antibodies rather than IgG anti-Dsg3 antibodies. Our case suggests that anti-Dsc3 antibodies may be pathogenic in cases positive for the dual cadherin autoantibodies.

References

Jan 1, 1995·The Journal of Investigative Dermatology·M Amagai
Aug 1, 1997·The Journal of Investigative Dermatology·T HashimotoT Nishikawa
Apr 9, 2004·Nature Reviews. Molecular Cell Biology·Spiro GetsiosKathleen J Green
Aug 7, 2008·Journal of Cell Science·Jiangli ChenPeter J Koch
Oct 19, 2010·The American Journal of Pathology·Xuming MaoAimee S Payne
Feb 2, 2011·The American Journal of Pathology·David RafeiRüdiger Eming
Jun 28, 2012·European Journal of Dermatology : EJD·Yutaka HatanoSakuhei Fujiwara
Feb 3, 2015·The British Journal of Dermatology·N IshiiT Hashimoto

❮ Previous
Next ❯

Citations

Feb 18, 2017·The Australasian Journal of Dermatology·Masutaka Furue, Takafumi Kadono
Aug 27, 2021·Frontiers in Medicine·Thomas Schmitt, Jens Waschke
Sep 28, 2021·Frontiers in Immunology·Xavier Bosch-AmateAgustín España

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.