Atypical Presentation of Acquired Hypoganglionosis in a Patient Taking Clozapine

Case Reports in Gastrointestinal Medicine
Catherine GisiViktor Eysselein

Abstract

Acquired hypoganglionosis (HG) is a rare enteric gastrointestinal neuromuscular disorder previously associated with chronic inflammation that can lead to constipation, ileus, and even death. There is little known about the pathophysiology of acquired hypoganglionosis, and it is unclear if medications are related to the development of the disease. Clozapine is an atypical antipsychotic used to treat refractory schizophrenia that is well known for its side effects including agranulocytosis and gastrointestinal dysmotility. This is an unusual case of acquired hypoganglionosis in a patient with anticholinergic toxicity on clozapine therapy.

References

Sep 1, 1987·Gastroenterology·S Krishnamurthy, M D Schuffler
Aug 1, 1981·Clinical Pharmacology and Therapeutics·C A NaranjoD J Greenblatt
Aug 20, 2002·European Journal of Clinical Pharmacology·K RaaskaP J Neuvonen
Dec 13, 2006·Journal of Pediatric Surgery·Tomoaki TaguchiJunko Akiyoshi
Feb 14, 2012·The Australian and New Zealand Journal of Psychiatry·Anne Stark, James Scott
Sep 12, 2012·Nature Reviews. Gastroenterology & Hepatology·Kenton M SandersSean M Ward
Nov 13, 2012·The Journal of Clinical Psychiatry·Dan CohenPeter F J Schulte
Jun 20, 2014·Gastroenterology Report·Tom C DeRocheXiuli Liu
Jun 9, 2016·International Journal of Molecular Sciences·Ayala ShiraziJohn Lally
Jan 1, 2014·Frontline Gastroenterology·H L PhilpottP R Gibson
Sep 25, 2017·Journal of Medical Case Reports·Mark T OstermanIsaac Matthias
Dec 13, 2017·CNS Drugs·Dan Cohen
May 15, 2018·The American Journal of Case Reports·Mohammed Yousef AldossaryKhalid Sabr
Jul 27, 2018·Nature Reviews. Neuroscience·Meenakshi Rao, Michael D Gershon
Mar 8, 2019·World Journal of Gastrointestinal Surgery·Allan Mf KwokKimberly Hart

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Methods Mentioned

BETA
biopsies

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