Atypical Presentation of Methicillin-Susceptible Staphylococcus aureus Infection in a Dengue-Positive Patient: A Case Report with Virulence Genes Analysis

Pathogens
Soo Tein NgoiCindy Shuan Ju Teh

Abstract

Concurrent bacteraemia in patients with dengue fever is rarely reported. We report a case of a patient who initially presented with symptoms typical of dengue fever but later succumbed to septic shock caused by hypervirulent methicillin-susceptible Staphylococcus aureus (MSSA). A 50-year-old female patient with hypertension and diabetes mellitus presented with typical symptoms of dengue fever. Upon investigation, the patient reported having prolonged fever for four days prior to hospitalization. Within 24 hours post-admission, the patient developed pneumonia and refractory shock, and ultimately succumbed to multiple-organs failure. Microbiological examination of the blood culture retrieved a pan susceptible MSSA strain. Genomic sequence analyses of the MSSA strain identified genes encoding staphylococcal superantigens (enterotoxin staphylococcal enterotoxin C 3 (SEC3) and enterotoxin-like staphylococcal enterotoxins-like toxin L (SElL)) that have been associated with toxic shock syndrome in human hosts. Genes encoding important toxins (Panton-Valentine leukocidins, alpha-haemolysin, protein A) involved in the development of staphylococcal pneumonia were also present in the MSSA genome. Staphylococcus aureus co-infections in den...Continue Reading

References

Feb 20, 1998·The Pediatric Infectious Disease Journal·C Pancharoen, U Thisyakorn
Jan 11, 2000·Clinical Microbiology Reviews·M M DingesP M Schlievert
Jul 5, 2001·International Journal of Medical Microbiology : IJMM·S Arvidson, K Tegmark
Nov 15, 2006·Infection and Immunity·Juliane Bubeck WardenburgOlaf Schneewind
Jan 20, 2007·Science·Maria Labandeira-ReyM Gabriela Bowden
Jul 3, 2007·Internal Medicine·Satoshi SuzukiKazuhiko Koike
Dec 8, 2007·The Lancet Infectious Diseases·Tom van der Poll, Steven M Opal
Jul 22, 2008·Transactions of the Royal Society of Tropical Medicine and Hygiene·Manjari LahiriPaul Ananth Tambyah
Sep 3, 2010·The American Journal of Tropical Medicine and Hygiene·Seok Mui Wang, Shamala Devi Sekaran
Apr 12, 2012·Clinical Microbiology Reviews·Sebastian J van HalIain B Gosbell
Jul 5, 2012·BMJ Case Reports·Rajeev Peeyush NagassarKaren Judith Roye-Green
May 10, 2013·PLoS Neglected Tropical Diseases·Sing-Sin SamSazaly AbuBakar
May 3, 2014·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jonathan R CarapetisRoss Andrews
Nov 7, 2014·PLoS Neglected Tropical Diseases·Abdul Hamid Mohd-ZakiMaïna L'Azou
May 29, 2015·Clinical Microbiology Reviews·Steven Y C TongVance G Fowler
Aug 26, 2015·The American Journal of Tropical Medicine and Hygiene·Nobuyuki MiyataYouko Kosuge
Sep 5, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Tun-Linn TheinDavid C Lye
Sep 24, 2015·Disease Models & Mechanisms·Srikanth Mairpady ShambatAnna Norrby-Teglund
Mar 2, 2016·Annual Review of Pathology·Lena ThomerDominique Missiakas
Mar 5, 2016·Current Environmental Health Reports·Yien Ling HiiJoacim Rocklöv
Jun 13, 2016·Journal of Clinical Virology : the Official Publication of the Pan American Society for Clinical Virology·Cássia Fernanda EstofoleteMaurício Lacerda Nogueira
Aug 9, 2016·Medicine·Chin-Ming ChenChih-Cheng Lai
Sep 15, 2017·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·M Ellen AcreeMichael Z David
Nov 5, 2017·Current Opinion in Microbiology·Richard P Novick, Geeta Ram
Jan 14, 2018·Chest·Jacob C JentzerKianoush B Kashani
Sep 21, 2018·Critical Care : the Official Journal of the Critical Care Forum·Prashanth NandhabalanDuncan Wyncoll
Dec 12, 2018·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Ling-Shan SyueWen-Chien Ko

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