Atypical progressive multifocal leukoencephalopathy in a patient with antisynthetase syndrome

Internal Medicine
Moncef Belhassen-GarciaJose Angel Martin-Oterino

Abstract

Antisynthetase syndrome is a disorder belonging to the dermatomyositis/polymyositis group, with high rates of morbidity and mortality. We herein present the case of a 71-year-old man who was diagnosed with antisynthetase syndrome and treated with rituximab. Almost three years later, the patient showed right-sided hemiparesis that ultimately progressed to complete hemiplegia and advancing cognitive deterioration with a poor clinical outcome. The neuropathological diagnosis was progressive multifocal leukoencephalopathy. Treatment with rituximab for antisynthetase syndrome itself plays a fundamental role in the development of infectious complications.

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Apr 29, 2016·Rheumatology·Serena FasanoDavid A Isenberg
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