Atypical retinal pigment epithelial defects with retained photoreceptor layers: a so far disregarded finding in age related macular degeneration

BMC Ophthalmology
Helena Giannakaki-ZimmermannMarion R Munk

Abstract

To report patients with age-related macular degeneration and atypical central retinal pigment epithelium (RPE) defects not attributable to geographic atrophy (GA) or RPE-tears with overlying preserved photoreceptor layers. Multimodal imaging case-series evaluating the course of atypical RPE- defects in patients with AMD using Color fundus images, Optical coherence tomography (OCT), OCT-Angiography, fundus autofluorescence (FAF) and fluorescein-angiography (FA). Ten patients were identified. Three patients had a prior RPE-rip and were excluded. Seven patients with a mean follow-up period of 47 ± 38 months after the occurrence of the RPE-defect were included (age range 71-87 years). Mean distance Best corrected visual acuity (BCVA) at initial presentation was 0.36 ± 0.29logMAR and at last follow-up visit 0.51 ± 0.43logMAR. Patients presented with clinically apparent GA on funduscopy and FAF, but preserved photoreceptor layers on optical coherence tomography (OCT). On FA there was early hyperfluorescence and late pooling visible. Over time, migration of RPE/drusenoid material right above the Bruch's membrane with concomitant decrease of hypoautofluorescence was detectable in 4 cases. An enlargement of the RPE-defect was apparent i...Continue Reading

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Citations

Jul 20, 2018·Investigative Ophthalmology & Visual Science·Mayu MoriguchiHideaki Hara
Aug 8, 2020·Progress in Retinal and Eye Research·Steffen Schmitz-ValckenbergFrank G Holz
Jul 18, 2018·Retinal Cases & Brief Reports·Rodrigo Molina-PalleteRosa Dolz-Marco
Apr 27, 2021·American Journal of Ophthalmology Case Reports·Akie YoshinagaRyo Obata

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