Atypical Skeletal Muscle Profiles in Human Immunodeficiency Virus-Infected Asymptomatic Middle-Aged Adults

Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America
Thanh TranMonty Montano

Abstract

Human immunodeficiency virus (HIV)-infected individuals are at increased risk of age-associated functional impairment, even with effective antiretroviral therapy (ART). A concurrent characterization of skeletal muscle, physical function, and immune phenotype in aviremic middle-aged HIV-infected adults represents a knowledge gap in prognostic biomarker discovery. We undertook a prospective observational study of 170 middle-aged, HIV-infected ambulatory men and women with CD4+ T-cell counts of at least 350/µL and undetectable plasma viremia while on effective ART, and uninfected control participants. We measured biomarkers for inflammation and immune activation, fatigue, the Veterans Aging Cohort Study mortality index, and physical function. A subset also received a skeletal muscle biopsy and computed tomography scan. Compared to the uninfected participants, HIV-infected participants displayed increased immune activation (P < .001), inflammation (P = .001), and fatigue (P = .010), and in a regression model adjusting for age and sex displayed deficits in stair-climb power (P < .001), gait speed (P = .036), and predicted metabolic equivalents (P = .019). Skeletal muscle displayed reduced nuclear peroxisome proliferator-activated re...Continue Reading

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Citations

Aug 3, 2019·AIDS Research and Human Retroviruses·Jules Levin, Monty Montano
Aug 31, 2019·AIDS Research and Human Retroviruses·Mary Clare MastersKristine M Erlandson
Jan 9, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Brañas FátimaGuaraldi Giovanni
May 2, 2020·Cells·Burkitkan AkbaySvetlana Dokudovskaya
Mar 25, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Farah A Ramírez-MarreroValerie Wojna
Feb 8, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Fátima BrañasGiovanni Guaraldi
Nov 15, 2019·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Karol M PencinaMonty Montano
Jun 13, 2020·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Farah A Ramírez-MarreroValerie Wojna
Feb 16, 2021·AIDS Research and Human Retroviruses·Monty Montano
Dec 3, 2021·Journal of Medicinal Chemistry·Xiao-Fei ChenZifeng Yang

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