PMID: 9438460Jan 23, 1998Paper

Atypical squamous cells of undetermined significance: a comparative review of original and automated rescreen diagnosis of cervicovaginal smears with long term follow-up

Cancer
J F StastnyW J Frable

Abstract

There is an increasing number of articles regarding the long term follow-up of Papanicolaou (Pap) smears with the diagnosis of atypical squamous cells of undetermined significance (ASCUS). Much controversy exists regarding the management of patients with this diagnosis. In a prior study in 1992, the authors performed automated rescreening of 101 ASCUS cases and 91 negative (control) cases. They found that through PAPNET-directed rescreening, 35 of 101 ASCUS cases (35%) could be reclassified as a squamous intraepithelial lesion (SIL). These 192 women were followed since 1992 through manual look backs of subsequent Pap smears and surgical biopsies over a 4-year period. The population studied was comprised of predominantly black women between the ages of 14 and 85 years. The majority were considered a high risk population because many had a history of several sexual partners and multiple pregnancies. Eighteen of 74 patients (24.3%) with an original diagnosis of ASCUS were found on subsequent Pap smears to have an SIL. Only 4 of 64 patients (6%) who originally had a negative Pap smear subsequently were found to have a low grade squamous intraepithelial lesion (LGSIL) within 4 years. Through ordinal logistic regression analysis, it ...Continue Reading

References

Jul 1, 1995·Diagnostic Cytopathology·R AshfaqM H Saboorian
Dec 1, 1994·Diagnostic Cytopathology·J A Robb
Feb 1, 1994·American Journal of Clinical Pathology·L G KossL Mango
Jun 1, 1996·Diagnostic Cytopathology·S Keyhani-RofaghaR V O'Toole
Jun 1, 1996·Diagnostic Cytopathology·M J Kline, D D Davey

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Citations

Apr 20, 2001·Clinical Pediatrics·C D AroraR Lazebnik
Jul 27, 2000·Journal of Clinical Pathology·A al-NafussiE McGoogan
Apr 13, 1999·Obstetrical & Gynecological Survey·O Abulafia, D M Sherer
Aug 2, 2001·Journal of Midwifery & Women's Health·J Mashburn

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