Atypical transient ischemic attacks in thrombocythemia of various myeloproliferative disorders

Leukemia & Lymphoma
Jan Jacques MichielsPeter J Koudstaal

Abstract

Neurological symptoms of transient unsteadiness, dysarthria, dysphasia, dysbasia, transient monoor hemiparesis, hemiparesis, scintillating scotomas, amaurosis fugax, vertigo, dizziness, migraine accompaniments, syncope and seizures were the presenting manifestations of thrombocythemia in various myeloproliferative disorders. Erythromelalgia preceded or followed the neurologic ischemic attacks. The neurologic and ocular attacks usually had a sudden onset, lasted for a few seconds to several minutes and occurred independently or sequentially rather than simultaneously. This clinical syndrome is caused by platelet-mediated ischemic and thrombotic processes in the end-arterial microvasculature and reflects the existence of a platelet dependent and aspirin responsive arterial thrombophilia in thrombocythemia as novel disease entity, which confirms and elucidates Mitchell's hypothesis.

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Citations

May 23, 1998·Blood Reviews·S Willoughby, T C Pearson
Apr 3, 2012·Hematology/oncology Clinics of North America·Marina KremyanskayaRonald Hoffman
Jul 25, 2015·European Journal of Haematology·Andrea AroldiElena Maria Elli
Apr 25, 2006·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Ramesh BalasubramaniamDonald Falace
Mar 3, 2006·Blood Cells, Molecules & Diseases·Jan Jacques MichielsHuub H D M van Vliet
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Mar 4, 2020·Cancers·Charlotte LiisborgTorben Lykke Sørensen
Jan 26, 2005·British Journal of Haematology·M A Elliott, A Tefferi

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