'Atypical' tremor

European Neurology
J M HendersonJ G Morris

Abstract

The tremor present in a small number of patients who present with features of both Parkinson's disease (PD) and essential tremor (ET) is ill-defined. We therefore studied 8 such patients with 'atypical' tremor and compared them clinically to 11 PD and 10 ET patients in a double-blind, cross-over, placebo-controlled trial. Tremor was assessed via accelerometry and surface EMG. Tremor frequency and the acute tremorlytic response to propranolol were not useful in discriminating between groups. Over 80% of atypical and PD patients showed alternating EMG, whereas 90% of ET patients had synchronous EMG activity. Tremor amplitude improved by > 90% in 38% of atypical, 27% of PD and none of the ET patients after single-dose L-dopa/benserazide (300/75 mg), a response which was significantly different between the ET and PD groups. Failure to differentiate electrophysiologically and pharmacologically between the atypical and other groups probably relates to clinical heterogeneity in the atypical group.

Citations

Sep 5, 2002·Movement Disorders : Official Journal of the Movement Disorder Society·Joseph Jankovic
Feb 17, 2000·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·I Milanov
Dec 19, 2001·Movement Disorders : Official Journal of the Movement Disorder Society·W OndoR K Simpson
Jan 22, 2003·The Cochrane Database of Systematic Reviews·N J CrosbyC E Clarke
Jun 2, 2001·Journal of the Royal Society of Medicine·B OgungboD Mendelow
Feb 6, 2008·Journal of Neural Transmission·R DjaldettiE Yaniv
Nov 25, 1998·Movement Disorders : Official Journal of the Movement Disorder Society·G DeuschlM Brin
Jul 2, 2008·Parkinsonism & Related Disorders·I MilanovD Georgiev

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