PMID: 1203621Nov 1, 1975Paper

Atypical tryptamine receptors in sheep pulmonary vein

British Journal of Pharmacology
P Eyre

Abstract

Both the pulmonary artery and vein of the sheep contracted dose-dependently to histamine, carbamoylcholine, prostaglandin F2a, noradrenaline and bradykinin and relaxed in the presence of isoprenaline or prostaglandin E1. 2 The effect of 5-hydroxytryptamine (5-HT) on the artery was consistently to produce dose-dependent contractions without tachyphylaxis. The effect on the vein was biphasic. 5HT 5 X 10(-10) to 5 X 10(-8) M relaxed the partially constricted vein. 5-HT 10(-7) to 10(-6) m caused brief venoconstriction followed by relaxation. 5-HT greater than 10(-6) M caused dose-related contraction of the vein. 3 Methysergide effectively blocked the contractile response of the artery to 5-HT, but only weakly inhibited the contractions of the vein (dose-ratio less than 20). 4 Each of ten antagonists tested failed to inhibit the 5-HT-induced relaxation of the vein. Sheep pulmonary vein possesses tryptamine receptors which mediate relaxation and which are not of the classicl M- or D-type. These receptors appear not to be involved directly or indirectly with responses to acetylcholine, catecholamines, histamine or prostaglandins.

References

Dec 1, 1966·The American Journal of Physiology·M Wurzel
Jul 1, 1974·British Journal of Pharmacology·Y S Bakhle, T W Smith
Jun 1, 1972·Zentralblatt für Veterinärmedizin. Reihe A·H J Schatzmann, H Gerber
Jul 8, 1972·The Veterinary Record·P Eyre
Sep 1, 1957·British Journal of Pharmacology and Chemotherapy·J H GADDUM, Z P PICARELLI
Jan 1, 1955·Quarterly Journal of Experimental Physiology and Cognate Medical Sciences·J H GADDUMF F STEPHENS

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Citations

Jan 1, 1978·Naunyn-Schmiedeberg's Archives of Pharmacology·J R Fozard, A T Ali
Dec 1, 1985·Agents and Actions·P O Ogunbiyi, P Eyre
Apr 1, 1978·Agents and Actions·N Chand, P Eyre
Dec 9, 1983·European Journal of Pharmacology·W FeniukA D Watts
Feb 6, 1990·European Journal of Pharmacology·A ContiP Biglioli
Jan 1, 1982·International Journal of Immunopharmacology·K B Mirbahar, P Eyre
Sep 1, 1984·Journal of Veterinary Pharmacology and Therapeutics·K B Mirbahar, P Eyre
Mar 31, 2016·Autonomic & Autacoid Pharmacology·J M Keppel Hesselink
Sep 1, 1977·The Journal of Pharmacy and Pharmacology·D E Burleigh
Jul 30, 1984·Life Sciences·M A TrevethickP P Humphrey

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