Atypical uterine leiomyoma: a case report and review of the literature

Journal of Medical Case Reports
Suzana Manxhuka-KerliuLabinot Shahini

Abstract

Atypical uterine leiomyomas show benign behavior. However, the distinction between leiomyomas and leiomyosarcomas may at times be problematic. We report a rare case of atypical uterine leiomyoma. We try to investigate potential immunohistochemical parameters that could be essential to distinguish cases of malignant smooth muscle tumors and those of uncertain or borderline histology. A 56-year-old white ethnic Albanian woman from Kosovo presented with uterine bleeding because of uterine multiple leiomyomas. A hysterectomy with unilateral adnexectomy was performed. Her hysterectomy specimen contained multiple leiomyomas in submucosal, intramural and subserosal locations. The leiomyomas were well demarcated, firm and white with a whorled cut surface and one had foci of hemorrhage. Histology of most of the leiomyomas showed a whorled (fascicular) pattern of smooth muscle bundles separated by well-vascularized connective tissue. Smooth muscle cells were elongated with eosinophilic or occasional fibrillar cytoplasm and distinct cell membranes. Some of them developed areas of degeneration including hyaline change, with less than five mitotic figures per ten high power fields in most mitotically active areas, and no significant atypia....Continue Reading

References

Apr 1, 1995·Human Pathology·T H NiemannR A Robinson
Apr 7, 2004·Fertility and Sterility·Klaus BodnerKlaus Mayerhofer
Dec 14, 2004·Gynecologic Oncology·Barbara Bodner-AdlerKlaus Mayerhofer
Dec 29, 2007·The American Journal of Surgical Pathology·Kristen A AtkinsLaurel W Rice
May 7, 2009·The American Journal of Surgical Pathology·Philip P C IpPhilip B Clement
Oct 24, 2009·International Journal of Gynecological Pathology : Official Journal of the International Society of Gynecological Pathologists·Chang Ohk SungDuk-Soo Bae
Sep 30, 2010·Archives of Gynecology and Obstetrics·Nurcan Uluskan ÜnverErtugrul Colak
Apr 5, 2013·The American Journal of Surgical Pathology·Amy LyTeri A Longacre

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Citations

Apr 17, 2018·Clinics and Practice·Tagore SunkaraVinaya Gaduputi

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Methods Mentioned

BETA
hysterectomy

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