Atypical Variant of Guillain Barre Syndrome in a Patient with COVID-19

The Journal of Critical Care Medicine
Megan M LoweryCynthia S Tsai

Abstract

A rare variant Miller Fisher Syndrome overlap with Guillain Barre Syndrome is described in an adult patient with SARS-COV-2 infection. The clinical course of a 45-year-old immunosuppressed man is summarized as a patient who developed ataxia, ophthalmoplegia, and areflexia after upper respiratory infection symptoms began. A nasopharyngeal swab was positive for COVID-19 polymerase chain reaction. He progressed to acute hypoxemic and hypercapnic respiratory failure requiring intubation and rapidly developed tetraparesis. Magnetic resonance imaging of the spine was consistent with Guillain Barre Syndrome. However, the clinical symptoms, along with positive anti-GQ1B antibodies, were consistent with Miller Fisher Syndrome and Guillain Barre Syndrome overlap. The patient required tracheostomy and had limited improvement in his significant neurological symptoms after several months. The case demonstrates the severe neurological implications, prolonged recovery and implications in the concomitant respiratory failure of COVID-19 patients with neurological symptoms on the spectrum of disorders of Guillain Barre Syndrome.

References

Apr 23, 1992·The New England Journal of Medicine·A H Ropper
Apr 26, 2001·Neurology·M MoriT Hattori
Oct 25, 2008·Journal of Neurology, Neurosurgery, and Psychiatry·K FunakoshiN Yuki
Dec 3, 2009·Journal of Neuro-ophthalmology : the Official Journal of the North American Neuro-Ophthalmology Society·Lee A SnyderNeil R Miller
Feb 15, 2011·Journal of the Neurological Sciences·Yusuf A RajaballyAntonino Uncini
Aug 19, 2011·Journal of the Neurological Sciences·Nortina ShahrizailaNobuhiro Yuki
Jul 7, 2012·Journal of Neurology, Neurosurgery, and Psychiatry·Thirugnanam UmapathiNobuhiro Yuki
Jul 30, 2014·Nature Reviews. Neurology·Benjamin R WakerleyUNKNOWN GBS Classification Group
Mar 8, 2016·Lancet·Hugh J WillisonPieter A van Doorn
Sep 27, 2016·Autoimmunity Reviews·Susanna Esposito, Maria Roberta Longo
Jul 28, 2017·Journal of Clinical Neurology·Jee Eun KimJae Phil Choi
Sep 25, 2018·Neurology. Neuroimmunology and Neuroinflammation·Keisuke YoshikawaSusumu Kusunoki
Feb 28, 2020·The Journal of Critical Care Medicine·Adina StoianAdrian Balasa
Feb 28, 2020·Journal of Medical Virology·Yan-Chao LiTsutomu Hashikawa
Apr 3, 2020·Brain, Behavior, and Immunity·Yeshun WuChun Yang
Apr 18, 2020·The New England Journal of Medicine·Gianpaolo ToscanoGiuseppe Micieli
Apr 19, 2020·Neurology·Consuelo Gutiérrez-OrtizJulián Benito-León
May 11, 2020·Journal of the Peripheral Nervous System : JPNS·Erika ScheidlBenjamin Bereznai

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Citations

Feb 10, 2021·Journal of the Neurological Sciences·Ariane LewisKara R Melmed
Feb 23, 2021·Journal of Neurology·Jason L ChanJustyna R Sarna
Mar 26, 2021·BMC Infectious Diseases·Jana WernerIlijas Jelcic
Feb 19, 2021·European Journal of Physical and Rehabilitation Medicine·Alessandro de SireUNKNOWN International Multiprofessional Steering Committee of Cochrane Rehabilitation REH-COVER Action
Jun 13, 2021·Environmental Science and Pollution Research International·Josef Finsterer
Aug 27, 2021·The International Journal of Neuroscience·Zeina Hassan OusseiranWafaa Takash Chamoun

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