Atypical virulence in a type III Toxoplasma gondii strain isolated in Japan

Parasitology International
Yuji TaniguchiYasuhiro Takashima

Abstract

The virulence of a type III Toxoplasma gondii strain isolated in Japan and designated here as TgCatJpGi1/TaJ was examined in mice and micro minipigs in this study. Despite its type III genotype, oral or intraperitoneal inoculation of cysts from it resulted in severe virulence in C57BL/6J and BALB/c mice. In contrast, mice inoculated with a high dose of TgCatJpGi1/TaJ tachyzoites showed no obvious clinical signs of infection, and all of them survived for >21 days post-inoculation. Furthermore, no clinical signs of infection were seen when micro minipigs were inoculated with 900 cysts. Interestingly, our allelic type screening of the virulence-related rop5, rop16, rop17, and rop18 genes, as based on restriction fragment length polymorphism analysis (RFLP), revealed that the RFLP patterns for TgCatJpGi1/TaJ were identical to those from nonvirulent type III parasites. These results suggest that TgCatJpGi1/TaJ possesses an unknown virulence factor or factors.

Citations

Nov 9, 2018·The Journal of Veterinary Medical Science·Mami MurakamiKohji Maruo
Aug 30, 2019·Transboundary and Emerging Diseases·Afsaneh AmoueiAhmad Daryani
Dec 18, 2020·Frontiers in Veterinary Science·Mercedes Fernández-EscobarLuis Miguel Ortega-Mora
Jul 10, 2020·Veterinary Parasitology·J P DubeyC Su
Jun 4, 2021·International Journal for Parasitology·Taizo SaitoYasuhiro Takashima
Jun 12, 2021·Veterinary Research·Mercedes Fernández-EscobarLuis Miguel Ortega-Mora
Dec 31, 2021·Parasitology International·Abdelbaset E AbdelbasetMakoto Igarashi

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