Atypical/Nor98 scrapie: properties of the agent, genetics, and epidemiology

Veterinary Research
Sylvie L BenestadMaria Nöremark

Abstract

Atypical/Nor98 scrapie cases in sheep were diagnosed for the first time in Norway in 1998. They are now identified in small ruminants in most European countries and represent an increasingly large proportion of the scrapie cases diagnosed in Europe. Atypical/Nor98 scrapie isolates have shown to be experimentally transmissible into transgenic mice and sheep but the properties of the TSE agent involved, like its biological and biochemical features, are so clearly distinct from the agent involved in classical scrapie that they have provided a challenging diagnostic for many years. No strain diversity has yet been identified among the atypical/Nor98 scrapie sample cases. The genetic predisposition of the sheep affected by atypical/Nor98 scrapie is almost inverted compared to classical scrapie, and the exact origin of this sporadic TSE strain is still speculative, but a spontaneous, non-contagious origin, like sporadic Creutzfeldt-Jakob disease in humans, can not be excluded. Further transmission and epidemiological studies are needed to better address this hypothesis.

References

Apr 10, 1997·Nature·R A SomervilleJ Hope
Apr 22, 1999·The Journal of General Virology·M A TranulisM J Ulvund
Sep 6, 2001·Preventive Veterinary Medicine·P HoppJ Jarp
Sep 6, 2003·The Veterinary Record·S L BenestadB Bratberg
Aug 11, 2004·The Journal of General Virology·Anne BuschmannMartin H Groschup
Sep 10, 2004·Current Molecular Medicine·M Baylis, W Goldmann
Oct 16, 2004·The Journal of General Virology·Leonor OrgeJ Pedro Simas
Dec 3, 2004·The Veterinary Record·H OnnaschH F Bassett
Dec 14, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·D Gavier-WidénC Hård af Segerstad
Dec 18, 2004·The Journal of General Virology·Truls MoumSylvie L Benestad
Dec 21, 2004·The Veterinary Record·H De BosschereE Vanopdenbosch
Feb 15, 2005·Biochemical and Biophysical Research Communications·Hiroko K HayashiMorikazu Shinagawa
Oct 22, 2005·Proceedings of the National Academy of Sciences of the United States of America·Annick Le DurHubert Laude
Jan 5, 2006·European Journal of Human Genetics : EJHG·Simon Mead
May 13, 2006·The Journal of General Virology·Mikael KlingebornTommy Linné
Oct 13, 2006·The Journal of General Virology·G C SaundersO Windl
Nov 14, 2006·The Journal of General Virology·Petter HoppBerit T Heier
Dec 13, 2006·Veterinary Research·Gesine LühkenGeorg Erhardt
Feb 15, 2007·BMC Veterinary Research·Timm KonoldMarion M Simmons
Apr 27, 2007·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Torsten SeuberlichAndreas Zurbriggen
May 15, 2007·The Veterinary Record·M E BruceU Agrimi
Jun 8, 2007·Emerging Infectious Diseases·Brent L RaceRichard E Race
Jun 15, 2007·PLoS Pathogens·Alice NentwigTorsten Seuberlich
Jun 23, 2007·Nature Reviews. Molecular Cell Biology·Adriano AguzziMagdalini Polymenidou

❮ Previous
Next ❯

Citations

Aug 10, 2010·Acta Neuropathologica·Jonathan D F Wadsworth, John Collinge
Apr 1, 2011·Journal of Clinical Microbiology·Ilias G BouzalasTorsten Seuberlich
Jul 24, 2010·Interdisciplinary Perspectives on Infectious Diseases·Sílvia SisóMartin Jeffrey
Feb 18, 2011·Veterinary Research·Martin EidenMartin H Groschup
Feb 18, 2011·Veterinary Research·Wiebke M WemheuerWalter J Schulz-Schaeffer
Nov 3, 2011·Virology Journal·Muhammad Imran, Saqib Mahmood
Jan 10, 2009·BMC Veterinary Research·Angel Ortiz-Pelaez, Víctor J Del Río Vilas
Feb 12, 2009·BMC Veterinary Research·Hugh A SimmonsAnthony E Wrathall
Mar 30, 2010·BMC Veterinary Research·Ana B Rodríguez-MartínezRamón A Juste
Apr 20, 2010·BMC Veterinary Research·Chantal HäusermannTorsten Seuberlich
May 4, 2010·BMC Veterinary Research·Michael P HeatonWilliam W Laegreid
Jul 27, 2012·BMC Veterinary Research·Maria HautaniemiLiisa Sihvonen
Feb 25, 2011·PLoS Pathogens·Olivier AndréolettiCaroline Lacroux
Jan 5, 2012·PLoS Pathogens·Pekka KujalaPeter J Peters
May 1, 2009·Emerging Infectious Diseases·Alexandre FediaevskyDidier Calavas
May 3, 2011·Emerging Infectious Diseases·Marion M SimmonsJohn Spiropoulos
Nov 6, 2013·Emerging Infectious Diseases·Jonathan D F WadsworthJohn Collinge
Aug 16, 2014·BioMed Research International·Sujeong YangRaymond Bujdoso
Aug 19, 2015·The Journal of General Virology·Angela ChongNora Hunter
Jan 24, 2014·International Journal of Cell Biology·Ilaria PoggioliniPiero Parchi
Mar 23, 2012·The Biochemical Journal·Alana M ThackrayRaymond Bujdoso
May 21, 2015·ILAR Journal·Justin J Greenlee, M Heather West Greenlee
Jan 20, 2011·Veterinary Pathology·S LezmiA Bencsik
Apr 23, 2017·The Veterinary Record·Giuseppe Ru
Sep 3, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Christina M LoiaconoS Mark Hall
May 11, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Gordon B MitchellAru Balachandran
Nov 23, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Torsten SeuberlichAndreas Zurbriggen
Nov 20, 2010·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Reinhold KittelbergerJoseph S O'Keefe
Nov 11, 2009·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Paul R WebbYvonne I Spencer
Nov 19, 2015·Biology·Kevin C GoughBen C Maddison

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved