AU-rich element-binding proteins in colorectal cancer

World Journal of Gastrointestinal Oncology
Noémie LegrandCyril Sobolewski

Abstract

Trans-acting factors controlling mRNA fate are critical for the post-transcriptional regulation of inflammation-related genes, as well as for oncogene and tumor suppressor expression in human cancers. Among them, a group of RNA-binding proteins called "Adenylate-Uridylate-rich elements binding proteins" (AUBPs) control mRNA stability or translation through their binding to AU-rich elements enriched in the 3'UTRs of inflammation- and cancer-associated mRNA transcripts. AUBPs play a central role in the recruitment of target mRNAs into small cytoplasmic foci called Processing-bodies and stress granules (also known as P-body/SG). Alterations in the expression and activities of AUBPs and P-body/SG assembly have been observed to occur with colorectal cancer (CRC) progression, indicating the significant role AUBP-dependent post-transcriptional regulation plays in controlling gene expression during CRC tumorigenesis. Accordingly, these alterations contribute to the pathological expression of many early-response genes involved in prostaglandin biosynthesis and inflammation, along with key oncogenic pathways. In this review, we summarize the current role of these proteins in CRC development. CRC remains a major cause of cancer mortality ...Continue Reading

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Citations

Sep 17, 2020·International Journal of Molecular Sciences·Dobrochna DolickaMichelangelo Foti
Oct 23, 2020·Cellular and Molecular Gastroenterology and Hepatology·Antonio Di GraziaIvan Monteleone
Sep 29, 2020·Cellular and Molecular Gastroenterology and Hepatology·Dobrochna DolickaMichelangelo Foti
Jul 10, 2021·Clinica Chimica Acta; International Journal of Clinical Chemistry·Qian GongJinjin Wang

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Methods Mentioned

BETA
immunoprecipitation
transgenic
xenograft
neddylation

Software Mentioned

TargetsScan

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