Abstract
Aucubin (Au), an iridoid glycoside from natural plants, has antioxidative and anti-inflammatory bioactivities; however, its effects on a traumatic brain injury (TBI) model remain unknown. We explored the potential role of Au in an H2O2-induced oxidant damage in primary cortical neurons and weight-drop induced-TBI in a mouse model. In vitro experiments, the various concentrations of Au (50 μg/ml, 100 μg/ml, or 200 μg/ml) were added in culture medium at 0 h and 6 h after neurons stimulated by H2O2 (100 μM). After exposed for 12 h, neurons were collected for western blot (WB), immunofluorescence, and M29,79-dichlorodihydrofluorescein diacetate (DCFH-DA) staining. In vivo experiments, Au (20 mg/kg or 40 mg/kg) was administrated intraperitoneally at 30 min, 12 h, 24 h, and 48 h after modeling. Brain water content, neurological deficits, and cognitive functions were measured at specific time, respectively. Cortical tissue around focal trauma was collected for WB, TdT-mediated dUTP Nick-End Labeling (TUNEL) staining, Nissl staining, quantitative real time polymerase chain reaction (q-PCR), immunofluorescence/immunohistochemistry, and enzyme linked immunosorbent assay (ELISA) at 72 h after TBI. RNA interference experiments were perform...Continue Reading
References
Jun 15, 2005·Molecular Neurobiology·Baolu Zhao
Sep 19, 2006·Clinica Chimica Acta; International Journal of Clinical Chemistry·Shingo Yamada, Ikuro Maruyama
Feb 6, 2007·Seminars in Immunology·Kensuke Miyake
Jul 3, 2007·Free Radical Biology & Medicine·Jian WangSylvain Doré
Feb 2, 2008·Science in China. Series C, Life Sciences·Kun XueChongRen Xu
Aug 23, 2008·Antioxidants & Redox Signaling·Marcus J CalkinsJeffrey A Johnson
Jan 14, 2009·Phytotherapy Research : PTR·Hong-Yu XueYong-Ping Xu
Feb 5, 2010·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Edward D HallAyman G Mustafa
Apr 20, 2010·Lancet Neurology·Hester F LingsmaAndrew I R Maas
May 22, 2010·Journal of Veterinary Emergency and Critical Care·Allison Sande, Chad West
Dec 2, 2010·Molecular Biology Reports·Hong Yu XueYong Ping Xu
Jul 6, 2011·Phytotherapy Research : PTR·Hong-Yu XueYong-Ping Xu
Apr 12, 2012·The Journal of Trauma and Acute Care Surgery·Tie-Lei GaoZhi-Jun Fu
Jul 20, 2012·Molecular Biology Reports·Hong Yu XueLi Ji Jin
Apr 4, 2013·Antioxidants & Redox Signaling·Carolin CorneliusSalvatore Cuzzocrea
Nov 10, 2013·Cell Death & Disease·A SinghalA Ghorpade
May 9, 2014·Free Radical Biology & Medicine·Ke DingMengliang Zhou
Apr 16, 2015·International Journal of Environmental Research and Public Health·Chia-Ying KuoJo-Ting Tsai
May 27, 2016·Cell Death & Disease·Y YangW Yi
Nov 12, 2016·Toxicological Sciences : an Official Journal of the Society of Toxicology·Chunfeng LuShizhong Zheng
Feb 12, 2017·Nature Reviews. Neurology·Dennis W SimonPatrick M Kochanek
Feb 12, 2017·Free Radical Biology & Medicine·Hongming LvXinxin Ci
Feb 23, 2017·Molecular Neurobiology·Li Zhang, Handong Wang
Apr 14, 2017·JCI Insight·Qian LiJian Wang
Jun 15, 2017·Journal of Neuroinflammation·Jun ZengShizhong Zheng
Sep 15, 2017·Neuron·Yasir N JassamJoseph El Khoury
Jan 3, 2018·Nature Neuroscience·Philip A KragelTor D Wager
Mar 21, 2018·Journal of Neuroinflammation·Yue LuChun-Hua Hang
Apr 28, 2018·Circulation Research·Steven J ForresterKathy K Griendling
Jun 30, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Yan-Ling QiuDa-Qing Sun
Jul 4, 2018·Free Radical Biology & Medicine·Xiangsheng ZhangJian Wang
Jul 10, 2018·Neuroreport·Ying-Li ZhuYan-Qin Shen
Aug 22, 2018·Drug Design, Development and Therapy·Jiang FangMengliang Zhou
Oct 3, 2018·Frontiers in Neuroscience·Yam Nath PaudelIekhsan Othman
Dec 17, 2018·Free Radical Biology & Medicine·Junmin WangJian Wang
Dec 24, 2018·Redox Biology·Farzane SivandzadeLuca Cucullo
Jan 23, 2019·Neurochemical Research·Siyu ChenDong-Sheng Ouyang
Mar 21, 2019·Frontiers in Pharmacology·Lei LiuSylvain Doré
Apr 6, 2019·Journal of Cellular and Molecular Medicine·Bingyu ShenHaihua Feng
Aug 20, 2019·The Journal of Surgical Research·Han WangWei Li
Dec 4, 2019·Fitoterapia·Xiangchang ZengDongsheng Ouyang
Dec 16, 2019·Neuropharmacology·Clifford L EastmanThota Ganesh
Citations
Dec 31, 2020·Human & Experimental Toxicology·Xiaobin LiuJinning Song
Dec 18, 2020·Life Sciences·Jie ChengWeibin Sheng
Apr 6, 2021·Pharmacology & Therapeutics·Ya-Qun ZhouDa-Wei Ye
May 18, 2021·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Ying Chun LiYan Jun Cao
Aug 3, 2021·Frontiers in Pharmacology·Chenxue MeiYuanyuan Wang
Jul 30, 2021·Brain Research·Chulei DengHandong Wang
Aug 8, 2021·Chinese Medicine·Lichuang HuangGang Cao
Sep 11, 2021·PloS One·Mariam J ShaheenJamilah M Borjac
Oct 7, 2021·Journal of Cellular and Molecular Medicine·Chen YueZhen Tan
Dec 5, 2021·Journal of Neurotrauma·Tao LiMeng-Liang Zhou