Audit of a screening service for fetal abnormalities using early ultrasound scanning and maternal serum alpha-fetoprotein estimation combined with selective detailed scanning

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
S E ChambersB B Muir

Abstract

The objective of the study was the evaluation of a screening service for fetal abnormality using early ultrasound scanning to date and establish viability of the pregnancy combined with maternal serum alpha-fetoprotein estimation at 16 weeks and thereafter selective detailed scanning at 18-20 weeks based on clinical indication. The study was designed to be retrospective, emphasizing the possibility of diagnosis. Early scans were performed by radiographers and radiologists, detailed ones by radiologists and obstetricians with subspecialty training in prenatal diagnosis. The study was carried out in the ultrasound department of a large University Hospital. The subjects studied were all cases of abnormality identified pre- or postnatally in women delivering in the hospital over 4 years and to whom the screening service applied. Information was obtained from ultrasound and maternity records, birth notifications, pathology and autopsy reports and a special needs register. Cases were classified as not detectable, potentially detectable and usually detectable. Major fetal anomalies numbered 255 (total deliveries 19,497), a prevalence of 1.3%; 130 (51%) were diagnosed by ultrasound with 64% before 24 weeks and 36% later. Eleven chromos...Continue Reading

Citations

Mar 24, 1998·Prenatal Diagnosis·L S Chitty, P P Pandya
Dec 1, 1995·Prenatal Diagnosis·L S Chitty
Jul 30, 1999·British Journal of Obstetrics and Gynaecology·N C Smith, C Hau
Jul 21, 1998·Annals of the New York Academy of Sciences·D W Skupski
Jul 21, 1998·Annals of the New York Academy of Sciences·S Levi
Aug 19, 2009·Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology·G RomosanL Valentin
Aug 30, 2008·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·Elena K Grant, Margaret J Evans
Mar 20, 2018·Case Reports in Obstetrics and Gynecology·Ugo IndraccoloPiergiorgio Fedeli
Feb 9, 1999·Pediatric and Developmental Pathology : the Official Journal of the Society for Pediatric Pathology and the Paediatric Pathology Society·C C SunJ S Dungan

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