Audit of the use of calcium carbonate as a phosphate binder in 100 patients treated with continuous ambulatory peritoneal dialysis

Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association
A DavenportJ C Mackenzie

Abstract

We studied the effect of converting 100 established CAPD patients from aluminium- to calcium-based phosphate binders. After a follow-up of 1 year only 60% of patients remained on calcium carbonate. Hypercalcaemia was the major problem, with more than 40% of patients having a serum calcium in excess of 3.0 mmol/l. Several patients required hospitalization for symptomatic hypercalcaemia. Hypercalcaemia was more common in patients with normal serum parathyroid hormone concentrations (65 versus 25%, P less than 0.01). Serum phosphate control was better prior to commencing calcium carbonate when patients were treated with aluminium phosphate binders mean 1.71 +/- 0.15 mmol/l (SEM) than at the time of maximum serum calcium concentration, 1.81 +/- 0.25, P less than 0.05. This study does not confirm the findings of others, which have suggested that calcium carbonate is a safe and effective phosphate binder for patients with end-stage renal failure.

Citations

Nov 12, 2005·Nephron. Clinical Practice·Juhani MyllymäkiJukka Mustonen
Nov 6, 2007·Journal of Korean Medical Science·In Seok LimHae Il Cheong
Jul 24, 2012·Clinical and Experimental Nephrology·Takashi TakeiKosaku Nitta
Oct 26, 2005·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tanja Kersnik LevartAlenka Vizjak
Mar 8, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isabel RobertiDae Un Kim
Aug 9, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Isabel RobertiDae Un Kim
Apr 18, 2009·Clinical and Experimental Nephrology·Akiko MiiYuh Fukuda
Aug 1, 2015·Peritoneal Dialysis International : Journal of the International Society for Peritoneal Dialysis·Cecile Courivaud, Andrew Davenport
Feb 25, 2010·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Scott E WenderferMichael C Braun
Oct 31, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Andrew DavenportUNKNOWN Pan Thames Renal Audit Group
Jan 1, 1993·Scandinavian Journal of Urology and Nephrology·A DavenportJ C Mackenzie

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