PMID: 15224868Jul 1, 2004Paper

Auditory function recovery following acoustic overstimulation

Acta Oto-laryngologica
J M Sánchez FernándezF Santaolalla Montoya

Abstract

To examine electrophysiological data from auditory brainstem responses (ABRs) and distortion product otoacoustic emissions (DPOAEs) in chickens following acoustic overstimulation. A total of 15 white 15-day-old Leghorn chickens were used. The animals were anesthetized with Equithensin, and placed with their heads in a special holder. Click stimuli were generated by a Nicolet CA1000 device and ABRs were recorded subcutaneously using three stainless-steel electrodes. An ILO 92/DP analyzer was used to determine DPOAEs. The noise was generated by a Promax GB 212 device. The acoustic exposure was provoked with a 2-kHz pure tone at 120 dB SPL for 24 h. ABRs and DPOAEs were determined before and immediately post-exposure and 5, 15, 21 and 30 days after the traumatic exposure. In our control DPgram response, the maximum amplitudes (dB SPL) occurred at 1, 1.5, 2, 3 and 4 kHz and the minimum amplitudes at 0.7, 5 and 6 kHz. Immediately following acoustic overstimulation an amplitude loss in all frequencies was detected (p < 0.001). Five days after noise exposure only the amplitude loss at 3 kHz remained. Three waves with positive and negative peaks appeared in our control ABR recordings. An important threshold shift was detected in the AB...Continue Reading

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