Auditory involvement in thalassemia major

Acta Haematologica
S De VirgiliisP Puxeddu


The auditory function of 75 children affected by homozygous beta0-thalassemia, managed with a low transfusion scheme and treated irregularly with low doses of desferrioxamine, and of 75 controls were examined. In 12 patients a mild bilateral conductive hearing impairment due to bony hypertrophy and/or adenoid hypertrophy was found. In 43 cases a moderate monolateral or bilateral sensory-neural hearing loss at high frequencies with recruitment phenomenon was observed. Ferritin levels were determined in a randomly chosen group of these patients with (14) and without heaing loss (11). In the subjects with sensory-neural hearing loss the mean ferritin levels were significantly higher than in those with no hearing defect. There was no obvious relation between sensory-neural damage on the one hand and Hb levels and unit of blood transfused on the other. The results of this study suggest that iron overload could be a cause of damage in the high frequency elements of the auditory mechanism. Intermittent hypoxia and slow 8th nerve compression due to bony hypertrophy as causes of auditory involvement are also discussed.


Apr 1, 1989·European Journal of Pediatrics·E A Llados i ValloryR Bourdon
Jan 5, 2002·Indian Journal of Pediatrics·M P Senanayake, S P Lamabadusuriya
May 1, 1996·International Journal of Pediatric Otorhinolaryngology·G KontzoglouM Athanassiou
May 1, 1995·American Journal of Otolaryngology·H KannoL P Rybak
May 1, 1988·Toxicology·M H FreedmanB Skarf
Jan 1, 1988·Toxicology in Vitro : an International Journal Published in Association with BIBRA·Z EstrovM H Freedman
Oct 13, 2007·The Journal of Laryngology and Otology·D ThioP Lennox
Apr 3, 1986·The New England Journal of Medicine·N F OlivieriB Skarf
Dec 14, 2005·Journal of Pediatric Hematology/oncology·Shu-Huey ChenHsi-Che Liu
Jul 1, 1989·Archives of Disease in Childhood·S P Lamabadusuriya
Aug 1, 1990·The Journal of Pediatrics·A CohenE Schwartz
Apr 1, 2006·Brain & Development·Dimitrios I ZafeiriouMiranta Athanasiou-Metaxa
Dec 1, 1987·The American Journal of Medicine·T GallantM H Freedman
Oct 12, 2000·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·U AmbrosettiM D Cappellini
Sep 21, 2018·Cochlear Implants International·Tanmaya KatariaMan Prakash Sharma
May 21, 2005·American Journal of Audiology·Letitia J WalkerWalter B Green
Jan 1, 1988·Audiology : Official Organ of the International Society of Audiology·R AlberaA Piga

Related Concepts

Acoustic Nerve
Conductive Hearing Loss
Sensory Hearing Loss
Internal Nerve Compression Syndromes
Hearing Impairment

Related Feeds


Anemia develops when your blood lacks enough healthy red blood cells. Anemia of inflammation (AI, also called anemia of chronic disease) is a common, typically normocytic, normochromic anemia that is caused by an underlying inflammatory disease. Here is the latest research on anemia.

Auditory Perception

Auditory perception is the ability to receive and interpret information attained by the ears. Here is the latest research on factors and underlying mechanisms that influence auditory perception.