PMID: 8970823Sep 15, 1996Paper

Auditory nerve neurophonic produced by the frequency difference of two simultaneously presented tones

Hearing Research
K R Henry

Abstract

When two phase-locked sinusoidal stimuli having frequencies of F1 and F2 are simultaneously introduced to the ear of the gerbil, a difference tone (DT) can be observed (DT = F2-F1, where F2 > F1) in the time-averaged electrical response recorded from the cochlear round window (RW). Tetrodotoxin (TTX), which blocks the axonal firing of the cochlear nerve fiber, greatly attenuates this DT response, suggesting it is primarily neural in origin. Alternating the polarity of a single phase-locked tone cancels out the RW cochlear microphonic (CM) from the time-averaged response, leaving a residual auditory nerve neurophonic (ANN) response if the stimulus frequency is low enough to result in phase-locked firing of cochlear nerve axons. Simultaneous presentation of 1 kHz (F1) and 2 kHz (F2) tones, each being phase-locked with alternating polarity, produces a small ANN in response to the original tones and a large time-averaged ANN in response to the DT. Even when the frequency of the individual tones is too high to support phase-locking, a large DT-ANN can also be measured in response to simultaneously presented tones. A robust time-averaged DT-ANN can be measured when the temporal and intensity relationships between F1 and F2 are varied...Continue Reading

References

Feb 1, 1991·Hearing Research·A L NuttallG Avinash
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Apr 1, 1993·The Journal of the Acoustical Society of America·A L Nuttall, D F Dolan

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Citations

Sep 11, 2007·Cerebral Cortex·Rossitza DraganovaChristo Pantev
Oct 11, 2012·Otology & Neurotology : Official Publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology·Baishakhi ChoudhuryOliver F Adunka
Jun 29, 2004·Hearing Research·Shaum P Bhagat, Craig A Champlin
Sep 24, 1999·The Journal of the Acoustical Society of America·K R Henry
Oct 17, 1998·Audiology : Official Organ of the International Society of Audiology·K R Henry

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