PMID: 8598546Mar 1, 1996Paper

Auditory startle response is diminished in rats after recovery from perinatal copper deficiency

The Journal of Nutrition
J R Prohaska, R G Hoffman

Abstract

Recovery from perinatal copper deficiency was studied in female and male Sprague Dawley rats for 6 mo. Month-old offspring reared by dams on copper-deficient treatment starting d 7 of pregnancy had up to 80% reductions in regional brain copper concentrations compared with offspring from copper-supplemented dams. Liver copper concentrations and plasma ceruloplasmin diamine oxidase activities of copper-deficient rats were restored to control levels within 1 mo of nutritional repletion with dietary copper. However, brain copper concentrations, with the exception of the hypothalamus and medulla, remain lower than in controls even after 5 mo of treatment. Rats were screened for startle responses and foot splay after 1, 3 and 5 mo of repletion. Diminished auditory startle was evident in rats of both sexes at all repletion times tested, whereas tactile startle and preimpulse inhibition of tactile startle were not influenced by prior copper deficiency, suggesting auditory sensory perception abnormalities. In a separate study, postweaning male rats deprived of dietary copper for 5 wk exhibited clear signs of copper deficiency but normal acoustic startle responses and foot splay. Long-term neurochemical and behavioral abnormalities persi...Continue Reading

Citations

Sep 28, 1999·The Journal of Nutrition·J R Prohaska, L J Heller
Nov 11, 2003·The Journal of Nutrition·Anna A Gybina, Joseph R Prohaska
Apr 16, 2005·The Proceedings of the Nutrition Society·Lorraine Gambling, Harry J McArdle
Nov 22, 2008·Biochemical Society Transactions·Lorraine GamblingHarry J McArdle
Apr 25, 2007·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Bonnie Ransom SternTom Starr
Sep 23, 2008·The Journal of Nutrition·Joshua W Pyatskowit, Joseph R Prohaska
May 6, 2003·The Journal of Nutrition·Carl L KeenMichael S Clegg
Jul 31, 2004·The Journal of Nutrition·James G Penland, Joseph R Prohaska
Apr 20, 2005·Journal of Neurochemistry·Joseph R Prohaska, Anna A Gybina
Jul 12, 2016·Metallomics : Integrated Biometal Science·Joseph R Prohaska
Jan 5, 2019·Journal of Neurovirology·Kristen A McLaurinCharles F Mactutus
Oct 9, 2002·The Journal of Nutrition·Joseph R Prohaska, Bruce Brokate
Feb 26, 1999·Brain Research. Molecular Brain Research·N J RutkoskiC W Levenson
Feb 2, 2006·Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology·Joseph R Prohaska, Margaret Broderius
Feb 9, 2007·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Joshua W Pyatskowit, Joseph R Prohaska
Jan 8, 2008·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Joshua W Pyatskowit, Joseph R Prohaska

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.