Auditory temporal acuity probed with cochlear implant stimulation and cortical recording.

Journal of Neurophysiology
Alana E Kirby, John C Middlebrooks

Abstract

Cochlear implants stimulate the auditory nerve with amplitude-modulated (AM) electric pulse trains. Pulse rates >2,000 pulses per second (pps) have been hypothesized to enhance transmission of temporal information. Recent studies, however, have shown that higher pulse rates impair phase locking to sinusoidal AM in the auditory cortex and impair perceptual modulation detection. Here, we investigated the effects of high pulse rates on the temporal acuity of transmission of pulse trains to the auditory cortex. In anesthetized guinea pigs, signal-detection analysis was used to measure the thresholds for detection of gaps in pulse trains at rates of 254, 1,017, and 4,069 pps and in acoustic noise. Gap-detection thresholds decreased by an order of magnitude with increases in pulse rate from 254 to 4,069 pps. Such a pulse-rate dependence would likely influence speech reception through clinical speech processors. To elucidate the neural mechanisms of gap detection, we measured recovery from forward masking after a 196.6-ms pulse train. Recovery from masking was faster at higher carrier pulse rates and masking increased linearly with current level. We fit the data with a dual-exponential recovery function, consistent with a peripheral a...Continue Reading

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Citations

Apr 7, 2010·Journal of the Association for Research in Otolaryngology : JARO·Ana Alves-PintoChristian J Sumner
Oct 5, 2011·Journal of the Association for Research in Otolaryngology : JARO·Alana E Kirby, John C Middlebrooks
Dec 13, 2012·The Journal of the Acoustical Society of America·John C Middlebrooks, Zekiye A Onsan
May 18, 2012·Journal of Neurophysiology·Kenneth E HancockBertrand Delgutte
May 6, 2011·Journal of Neurophysiology·Ralph E BeitelChristoph E Schreiner
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Jul 12, 2017·Frontiers in Neuroscience·Shuman HeCraig A Buchman
Mar 3, 2020·The Journal of the Acoustical Society of America·Martin J LindenbeckSridhar Srinivasan
Jul 7, 2017·The Journal of the Acoustical Society of America·Monita Chatterjee, Aditya M Kulkarni
May 7, 2019·Journal of Speech, Language, and Hearing Research : JSLHR·Sungmin LeeGavin M Bidelman

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