Auditory working memory impairments in individuals at familial high risk for schizophrenia.

Neuropsychology
Larry J SeidmanStephen V Faraone

Abstract

The search for predictors of schizophrenia has accelerated with a growing focus on early intervention and prevention of psychotic illness. Studying nonpsychotic relatives of individuals with schizophrenia enables identification of markers of vulnerability for the illness independent of confounds associated with psychosis. The goal of these studies was to develop new auditory continuous performance tests (ACPTs) and evaluate their effects in individuals with schizophrenia and their relatives. We carried out two studies of auditory vigilance with tasks involving working memory (WM) and interference control with increasing levels of cognitive load to discern the information-processing vulnerabilities in a sample of schizophrenia patients, and two samples of nonpsychotic relatives of individuals with schizophrenia and controls. Study 1 assessed adults (mean age = 41), and Study 2 assessed teenagers and young adults age 13-25 (M = 19). Patients with schizophrenia were impaired on all five versions of the ACPTs, whereas relatives were impaired only on WM tasks, particularly the two interference tasks that maximize cognitive load. Across all groups, the interference tasks were more difficult to perform than the other tasks. Schizophre...Continue Reading

Citations

Sep 16, 2014·Child and Adolescent Psychiatric Clinics of North America·Larry J Seidman
Oct 18, 2013·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·H W ThermenosL J Seidman
Mar 28, 2013·Developmental Psychobiology·G Andrew MickleyNita Hoxha
Jul 15, 2015·Schizophrenia Research·T C ManschreckL J Seidman
Dec 5, 2017·Journal of the International Neuropsychological Society : JINS·Larry J Seidman, Allan F Mirsky
Dec 3, 2016·Journal of the International Neuropsychological Society : JINS·Larry J SeidmanStephen V Faraone
Dec 7, 2017·Psychiatry Investigation·Noor Alaudin Abdul WahabSuzaily Wahab
Apr 8, 2020·Journal of Psychiatry and Brain Science·Kathryn E LewandowskiMartha E Shenton
Sep 14, 2017·American Journal of Medical Genetics. Part B, Neuropsychiatric Genetics : the Official Publication of the International Society of Psychiatric Genetics·M Leonor BustamanteHernán Silva
Jul 22, 2021·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jason SmucnyCameron S Carter
Sep 19, 2021·Schizophrenia Bulletin·Nina ZaksCarrie E Bearden

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