AUF1 and Hu proteins in the developing rat brain: implication in the proliferation and differentiation of neural progenitors

Journal of Neuroscience Research
Dolores HambardzumyanPhilippe Naveilhan

Abstract

Posttranscriptional events such as RNA stabilization are important for cell differentiation, but little is known about the impact of AU-rich binding proteins (AUBPs) on the fate of neural cells. Expression of destabilizing AUBPs such as AUF1 and neuronal-specific stabilizing proteins such as HuB, HuC and HuD was therefore analyzed in the developing central nervous system. Real-time RT-PCR indicated a specific developmental pattern in the postnatal cerebellum, with a progressive down-regulation of AUF1 from P1, whereas HuB was strongly up-regulated at about P7. These changes were accompanied by a progressive increase in AUF1p45 and the disappearance of one HuB isoform from P15, suggesting particular roles for these AUBPs in the developing cerebellum. AUF1 was detected in the three main cerebellar layers, whereas Hu proteins were found only in postmitotic neurons. A role for Hu proteins in the early stages of neuronal differentiation is further supported by arrest of cell proliferation following induction of HuB or HuD expression in a neural stem cell line. The decrease in nestin expression suggest that HuD, but not HuB, favors the transition of neural progenitors into early neuroblasts, but other factors are most probably requir...Continue Reading

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Citations

Sep 6, 2012·Proceedings of the National Academy of Sciences of the United States of America·Yong-Seok LeeBong-Kiun Kaang
Jun 26, 2012·Human Molecular Genetics·Brent L FogelDaniel H Geschwind
Jun 30, 2010·Molecular and Cellular Biology·Kotb AbdelmohsenMyriam Gorospe
Jun 2, 2011·BMC Genomics·Preethi H GunaratneDavid F Clayton
Aug 13, 2011·Thyroid Research·Bogusz TrojanowiczCuong Hoang-Vu
May 31, 2011·Frontiers in Bioscience (Landmark Edition)·Beth E Zucconi, Gerald M Wilson
Aug 26, 2015·Proceedings of the National Academy of Sciences of the United States of America·Feifei WangXinyu Zhao
Jan 20, 2012·Trends in Genetics : TIG·Claudio R Alonso
Apr 30, 2011·Neurobiology of Disease·Sophorn ChipSven Wellmann
Apr 19, 2011·Current Opinion in Genetics & Development·Irina Vlasova-St Louis, Paul R Bohjanen
Oct 20, 2009·Molecular and Cellular Neurosciences·Silvia De Rubeis, Claudia Bagni
Apr 2, 2014·Wiley Interdisciplinary Reviews. RNA·Ashleigh E MooreRobert J Schneider
Mar 24, 2016·Cell Biochemistry and Function·Do-Yeon Kim
Apr 8, 2015·Nature Neuroscience·Christopher L FrankAnne E West
Sep 9, 2016·American Journal of Medical Genetics. Part a·Xuyun HuYiping Shen
Mar 16, 2017·Scientific Reports·Apostolia FragkouliEpaminondas Doxakis

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