Augmentation controls the fast rebound from depression at excitatory hippocampal synapses

Journal of Neurophysiology
Elizabeth Garcia-Perez, J F Wesseling

Abstract

Short-term plasticity occurs at most central chemical synapses and includes both positive and negative components, but the principles governing interaction between components are largely unknown. The residual Ca(2+) that persists in presynaptic terminals for several seconds after repetitive use is known to enhance neurotransmitter release under artificial, low probability of release conditions where depression is absent; this is termed augmentation. However, the full impact of augmentation under standard conditions at synapses where depression dominates is not known because of possibly complicated convolution with a variety of potential depression mechanisms. This report shows that residual Ca(2+) continues to have a large enhancing impact on release at excitatory hippocampal synapses recovering from depression, including when only recently recruited vesicles are available for release. No evidence was found for gradual vesicle priming or for fast refilling of a highly releasable subdivision of the readily releasable pool (RRP). And decay of enhancement matched the clearance of residual Ca(2+), thus matching the behavior of augmentation when studied in isolation. Because of incomplete RRP replenishment, synaptic strength was not...Continue Reading

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Citations

Sep 18, 2009·Journal of Neurophysiology·Vladislav VolmanTerrence J Sejnowski
Oct 15, 2014·The Journal of General Physiology·Matthew J Van HookWallace B Thoreson
Feb 17, 2015·Epilepsia·Elizabeth García-PérezJohn F Wesseling
Jul 20, 2016·Proceedings of the National Academy of Sciences of the United States of America·Holger TaschenbergerErwin Neher
Apr 2, 2016·PLoS Computational Biology·Kashif MahfoozJohn F Wesseling
May 20, 2020·Frontiers in Synaptic Neuroscience·John M Bekkers

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