PMID: 7527864Dec 1, 1994Paper

Augmentation of alveolar macrophage phagocytic activity by granulocyte colony stimulating factor and interleukin-1: influence of splenectomy

The Journal of Trauma
J C HebertB Barry

Abstract

The use of cytokines and other naturally occurring substances as biopharmaceuticals for modulating the host response to trauma and infection offers new therapeutic possibilities. Cytokine pretreatment protects animals in a variety of experimental models, including splenectomized mice following pneumococcal aerosol challenge. Since splenectomy appears to affect alveolar macrophage function, we postulated that pretreatment with interleukin 1 (IL-1) and granulocyte colony stimulating factor (G-CSF) improved survival in mice following aerosol challenge of live pneumococci by activating alveolar macrophages. Alveolar macrophage bactericidal and phagocytic function was slightly, but consistently, depressed following splenectomy. Interleukin-1 and G-CSF pretreatment had pronounced effects on macrophage phagocytic and bactericidal activity, and these effects were quite different depending upon whether the mice were eusplenic or asplenic. Splenectomy augmented the effects of IL-1 on alveolar macrophage bactericidal function compared with eusplenic mice (p < 0.001), while more pronounced effects on macrophage function following G-CSF treatment were seen in mice with intact spleens (p < 0.001). The use of cytokines and other substances to...Continue Reading

Citations

Jun 22, 2001·Immunopharmacology and Immunotoxicology·M AltamuraS Miniello
Sep 11, 2008·Clinical and Experimental Immunology·F M TeixeiraH C Teixeira
Mar 8, 2003·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Carlos FelederClark M Blatteis
Aug 30, 2019·Laboratory animal research·Jun-Young KimYang-Kyu Choi

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