Augmentation of antigen-stimulated allergic responses by a small amount of trichloroethylene ingestion from drinking water

Regulatory Toxicology and Pharmacology : RTP
Makoto SeoHisamitsu Nagase

Abstract

In previous report, we have shown that trichloroethylene (TCE) increases histamine release and inflammatory cytokine production from antigen-stimulated mast cells. In this study, we examined the enhancing effect of a small amount of TCE ingestion from drinking water on antigen-stimulated allergic responses. After exposure of Wistar rats to TCE ingestion for 2 or 4 weeks, we performed a passive cutaneous anaphylaxis (PCA) reaction. TCE ingestion for 2 and 4 weeks enhanced PCA reaction in a dose-dependent manner. On histological examination, TCE ingestion for 2 weeks exacerbated inflammation characterized by infiltration of lymphocytes and accumulation of mast cells around the vessel in the skin. After TCE ingestion for 4 weeks, the mesenteric lymph nodes (MLNs) showed increase of the size and wet weight, and germinal centers changed distinctly. The interleukin-4 (IL-4) mRNA levels on spleen, MLNs and leukocytes were increased. Moreover, serum total IgE levels of TCE ingestion increased in a time-dependent manner. Our results suggest that TCE ingestion induces pro-inflammatory responses and causes Th1/Th2-type helper T-cell imbalance. And more, a small amount of TCE ingestion may lead to the initiation and acceleration of type I ...Continue Reading

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Citations

Jul 6, 2014·Occupational and Environmental Medicine·Emma BajeuxFabienne Pelé
Apr 3, 2012·The Journal of Toxicological Sciences·Ryo KobayashiHisamitsu Nagase
Apr 3, 2012·The Journal of Toxicological Sciences·Makoto SeoHisamitsu Nagase
Oct 13, 2017·Toxicology and Industrial Health·Jia-Xiang ZhangQi-Xing Zhu

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