PMID: 489165Aug 1, 1979Paper

Augmentation of cell-mediated cytotoxicity to a rat lymphoma. I. Stimulation of non-T-cell cytotoxicity in vivo by tumour cells

International Journal of Cancer. Journal International Du Cancer
H J Dawkins, G R Shellam

Abstract

The injection of a syngeneic Gross-virus-induced lymphoma into W/Fu rats induced peaks of cytotoxicity in the spleen attributable to non-T cells and T cells 3 and 10 days later, respectively. The conditions required for augmenting the cytotoxicity of the non-T cells in various lymphoid compartments (shown elsewhere to closely resemble NK cells) were analysed using the ip and iv routes of inoculation and a variety of tumour cells including those normally susceptible or resistant to lysis by NK cells in vitro. Using an ip inoculation of W/FuG-1 cells (a tumour susceptible to lysis by NK cells), a short-lived, 3-fold increase in cytotoxicity was observed in the spleen at day 3 and a 5-fold increase in the PEC at day 5. Cytotoxicity in other lymphoid organs remained unchanged. Tumours resistant to lysis by NK cells also stimulated cytotoxicity in the spleen or PEC, although the effect depended on the dose and route of inoculation used, and depression of cytotoxicity was observed under some conditions.

References

Jun 1, 1976·Journal of the National Cancer Institute·M Glaser, R Herberman
Feb 15, 1977·International Journal of Cancer. Journal International Du Cancer·G R Shellam
Feb 15, 1978·International Journal of Cancer. Journal International Du Cancer·J R OehlerR B Herberman
Feb 15, 1978·International Journal of Cancer. Journal International Du Cancer·J R OehlerR B Herberman
Aug 12, 1976·Nature·S A WolfeC S Henney
Feb 15, 1977·International Journal of Cancer. Journal International Du Cancer·G R Shellam, N Hogg
Apr 15, 1977·International Journal of Cancer. Journal International Du Cancer·R B HerbermanJ Y Djeu
Feb 1, 1976·Journal of the National Cancer Institute·M E NunnR B Herberman
Mar 15, 1976·International Journal of Cancer. Journal International Du Cancer·J BruceG R Shellam
Jul 15, 1974·International Journal of Cancer. Journal International Du Cancer·G R Shellam

❮ Previous
Next ❯

Citations

Mar 1, 1983·Biulleten' eksperimental'noĭ biologii i meditsiny·V A Lavrovskiĭ, R M Ibragimov
Feb 1, 1985·Cellular Immunology·J P FlexmanG R Shellam
Aug 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·G R ShellamG J Bancroft
Feb 15, 1980·International Journal of Cancer. Journal International Du Cancer·P HerseyW H McCarthy
Dec 1, 1981·International Journal of Cancer. Journal International Du Cancer·G R Flannery, C G Brooks
Mar 15, 1983·International Journal of Cancer. Journal International Du Cancer·I KawaseC S Henney
Nov 13, 1984·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·B A Askonas, G J Bancroft
Mar 15, 1980·International Journal of Cancer. Journal International Du Cancer·G R ShellamH J Dawkins

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.