Augmentation of cell-mediated immunotherapy against herpes simplex virus by interleukins: comparison of in vivo effects of IL-2 and IL-7 on adoptively transferred T cells

Vaccine
P WiryanaR J Ho

Abstract

We investigated the ability of human recombinant interleukin-7 (IL-7) to enhance cytotoxic T lymphocyte (CTL) activity in vivo using mice infected with herpes simplex virus type-1 (HSV-1). IL-7 or interleukin-2 (IL-2) was administered twice daily to immune naive mice subjected to adoptive transfer of immune T cells after infection with HSV-1. The immunotherapeutic effect was measured by detecting the virus recovered from pinna. Administration of HSV-1 immune T cells to naive mice significantly increased their ability to clear the virus. Twice-daily injections of IL-7 at 200 IU provided an additional 20-fold reduction in virus load, compared with T cell therapy alone (P < 0.0005). Combining IL-2 and T cell therapy provided about a sevenfold reduction compared with T cell therapy alone (P < 0.0009). IL-7 also enhanced the antiviral effects of T cell therapy against HSV-1 through the enhancement of CD8+ CTLs, as observed with IL-2. These results indicate that IL-7 may be used adjunct to adoptive T lymphocyte therapy in modulating human viral diseases and cancer through enhanced immune T cell activities.

References

Jan 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·R G GoodwinA E Namen
Jan 1, 1995·Annual Review of Immunology·S R Riddell, P D Greenberg

❮ Previous
Next ❯

Citations

Nov 2, 2004·Nature Reviews. Immunology·Marcel R M van den BrinkRichard L Boyd
Aug 28, 2004·Journal of Virology·Marcin MoniuszkoGenoveffa Franchini
Jan 14, 2010·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Claude SportèsRonald E Gress
Jun 30, 2012·Cytokine & Growth Factor Reviews·Sheila M KeatingPhilip J Norris
Dec 15, 2004·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Hailing LuJan Storek
Feb 6, 2010·Expert Opinion on Biological Therapy·Jennifer A WestwoodMichael H Kershaw
May 16, 2002·Blood·Terry J Fry, Crystal L Mackall
Sep 9, 2005·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sian M HensonRichard Aspinall
Aug 28, 2020·Sexually Transmitted Infections·Andile MtshaliLenine J P Liebenberg

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.

Antivirals (ASM)

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Antivirals

Antivirals are medications that are used specifically for treating viral infections. Discover the latest research on antivirals here.

Related Papers

Journal of Pediatric Endocrinology & Metabolism : JPEM
B A CrawfordD J Handelsman
Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Ronald J BoschAIDS Clinical Trials Group A5132 Team
Biology of Blood and Marrow Transplantation : Journal of the American Society for Blood and Marrow Transplantation
A E Patterson, R Korngold
© 2021 Meta ULC. All rights reserved