Augmentation of exposure therapy with D-cycloserine for social anxiety disorder

Archives of General Psychiatry
Stefan G HofmannMichael W Otto

Abstract

Social anxiety disorder (SAD) is common and debilitating. Although exposure therapy is one of the most effective forms of psychotherapy for this disorder, many patients remain symptomatic. Fear reduction in exposure therapy is similar to extinction learning, and early clinical data with specific phobias suggest that the treatment effects of exposure therapy for SAD may be enhanced with d-cycloserine, an agonist at the glutamatergic N-methyl-d-aspartate receptor. To determine whether short-term treatment with 50 mg of d-cycloserine enhances the efficacy of exposure therapy for SAD. Randomized, double-blind, placebo-controlled augmentation trial examining the combination of d-cycloserine or pill placebo with exposure therapy for SAD. Patients were self-referred from the general community to 1 of 3 research clinics. Twenty-seven participants meeting DSM-IV criteria for SAD with significant public speaking anxiety. Following a diagnostic interview and pretreatment assessment, participants received 5 therapy sessions delivered in either an individual or group therapy format. The first session provided an introduction to the treatment model and was followed by 4 sessions emphasizing exposure to increasingly challenging public speech ...Continue Reading

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Citations

Jan 16, 2014·Annual Review of Medicine·JoAnn DifedeJudith Cukor
Feb 12, 2014·Neurobiology of Learning and Memory·Kathryn D BakerRick Richardson
Mar 30, 2013·Annual Review of Clinical Psychology·Bram VervlietDirk Hermans
Aug 22, 2006·Biological Psychiatry·Kathleen C Anderson, Thomas R Insel
Aug 2, 2007·Journal of Psychiatric Practice·Joanna SteinglassB Timothy Walsh
Aug 30, 2007·Nature Neuroscience·Kerry J Ressler, Helen S Mayberg
Apr 25, 2008·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Mark R Dadds, Tracy Rhodes
May 15, 2008·Cerebral Cortex·Raffael KalischRaymond J Dolan
Sep 11, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bríd A Nic DhonnchadhaKathleen M Kantak
Feb 5, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bronwyn M Graham, Rick Richardson
Jul 16, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Karyn M MyersMichael Davis
Aug 19, 2010·Pharmacological Reviews·Stephen F TraynelisRay Dingledine
Oct 20, 2010·Journal of Cognitive Neuroscience·Daniel M Curlik, Tracey J Shors
Mar 30, 2011·Proceedings of the National Academy of Sciences of the United States of America·Dominique J-F de QuervainFrank H Wilhelm
Feb 22, 2012·Journal of Psychopharmacology·Floris KlumpersJohanna M P Baas
Jan 29, 2013·Nature Neuroscience·Ryan G Parsons, Kerry J Ressler
Sep 21, 2007·Current Psychiatry Reports·Jonathan M Amiel, Sanjay J Mathew
Jun 23, 2010·Current Psychiatry Reports·Dan J Stein, Jonathan C Ipser
Aug 25, 2007·Annual Review of Clinical Psychology·Alan E Kazdin
Jun 19, 2013·Biology of Mood & Anxiety Disorders·Stefan G HofmannHannah Boettcher
Jun 23, 2009·Science and Engineering Ethics·Nick Bostrom, Anders Sandberg
Jan 21, 2009·The Australian and New Zealand Journal of Psychiatry·Mark J BoschenAllison M Waters
Nov 27, 2008·Psychotherapy Research : Journal of the Society for Psychotherapy Research·Alan E Kazdin
Aug 31, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ami Citri, Robert C Malenka
Oct 25, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Shigeto YamamotoShigeto Yamawaki
Mar 21, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Julia M Langton, Rick Richardson
Mar 28, 2008·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Sheng-Chun MaoPo-Wu Gean
Feb 20, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Bronwyn M Graham, Rick Richardson
Aug 14, 2009·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Daisuke YamadaMasayuki Sekiguchi
Jul 2, 2010·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jessica McCallumRick Richardson
Dec 13, 2006·Molecular Psychiatry·K M Myers, M Davis
Aug 22, 2006·Biological Psychiatry·Gregory J Quirk
Sep 26, 2012·Expert Review of Neurotherapeutics·Kristy L Dalrymple
Aug 2, 2008·Expert Review of Neurotherapeutics·Vladan Starcevic
Jul 30, 2011·Expert Review of Neurotherapeutics·Carmen P McLean, Edna B Foa

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