Augmentation of growth hormone secretion after testosterone treatment in boys with constitutional delay of growth and adolescence: evidence against an increase in hypothalamic secretion of growth hormone-releasing hormone

The Journal of Clinical Endocrinology and Metabolism
Michael S RacineAriel L Barkan

Abstract

The increase in pituitary GH secretion that occurs during mid-late puberty in boys follows an increase in circulating testosterone (T) concentration; the direct mechanism by which this occurs is unknown. We hypothesized that T increases GH secretion during puberty by augmenting hypothalamic output of GHRH. Using constant infusions of a GHRH antagonist, we tested this hypothesis in six early pubertal boys with constitutional delay of growth and adolescence who had a mean chronological age of 14.0 +/- 0.3 yr and mean bone age of 11.4 +/- 0.2 yr. Blood samples were obtained from subjects every 15 min for 24 h during the overnight infusion of normal saline (2000-0600 h) and again during the overnight infusion of GHRH antagonist (0.33 microg/kg/h) the following night. Subjects then received transdermal T (5-mg patch) for 12 h nightly and were studied again after 4 wk of treatment. Serum samples were assayed for GH and total ghrelin; the percent suppression of GH during GHRH antagonist infusion was calculated. Morning serum T rose from 0.44 +/- 0.09 to 4.43 +/- 0.74 microg/liter (P = 0.005). T treatment was associated with a 92.6% increase in mean nocturnal GH secretion area under the curve (830 +/- 177 to 1599 +/- 340 microg/24 h.li...Continue Reading

Citations

Mar 19, 2005·Hormone Research·Denton HirshJean-Pierre Chanoine
Mar 30, 2005·Hormone Research·J-P Chanoine
Mar 6, 2007·Endocrinology and Metabolism Clinics of North America·Naila Goldenberg, Ariel Barkan
Aug 9, 2005·Endocrinology and Metabolism Clinics of North America·Brandon M Nathan, Mark R Palmert
Nov 23, 2006·The Journal of Clinical Endocrinology and Metabolism·Kerry J MackelvieJean-Pierre Chanoine

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