PMID: 6967945Sep 1, 1980Paper

Augmentation of in vitro humoral immune responses in the mouse by an antibody to IgD

The Journal of Experimental Medicine
F D FinkelhamI Scher

Abstract

Heterologous anti-delta-chain antibodies have an adjuvant effect on specific in vivo humoral immune responses to simultaneously, or subsequently, injected antigens in the rat and rhesus monkey. We have used a hybridoma-secreted antibody that binds murine delta-chain of the allotype (4.22aM delta a) to study this phenomenon in the mouse and to investigate the mechanism of this effect. Injection of 4.22aM delta a into BALB/c mice removes almost all surface IgD (sIgD) from splenic B lymphocites. sIgD does not reappear until the serum level of 4.22aM delta a decreased 5-7 d after injection. 4.22aM delta a fails to induce detectable proliferation or to raise total serum Ig levels substantially above control values. However, 4.22aM dalta a injected 24 h before antigen elicits an approximately twofold enhancement of serum IgM and a 3- to 10-fold enhancement of serum IgG anti-trintriphenyl (TNP) antibodies in response to immunization with optimal doses of TNP-Ficoll or TNP-sheep red blood cells (TNP-SRBC). 4.22aM delta a injected 1 wk before or 3 d after TNP-SRBC, however, has no effect on IgG anti-TNP levels. The adjuvant effect of anti-delta-chain antibody was markedly decreased when suboptimal antigen doses were used. Furthermore, e...Continue Reading

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Citations

Dec 30, 2014·Journal of Pharmacological and Toxicological Methods·John ShinAlexandra Hicks
Jan 1, 1982·Annals of the New York Academy of Sciences·M A CuchensG A Leslie
Jan 1, 1982·Annals of the New York Academy of Sciences·E S Vitetta
Jan 1, 1982·Annals of the New York Academy of Sciences·G J ThorbeckeE B Jacobson
Jan 1, 1982·Annals of the New York Academy of Sciences·E S MetcalfF D Finkelman
Nov 5, 1999·International Immunology·I Levan-PetitJ C Lecron
Mar 22, 2003·British Journal of Haematology·Eric G HaarmanAnjo J P Veerman

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