Augmentation of lipopolysaccharide-induced thymocyte apoptosis by interferon-gamma

Cellular Immunology
Y KatoT Yokochi

Abstract

The role of interferon (IFN)-gamma on thymocyte apoptosis in response to lipopolysaccharide (LPS) was investigated. The administration of LPS into mice induced marked apoptosis of thymocytes in vivo, but the simultaneous injection of anti-IFN-gamma antibody with LPS completely prevented thymocyte apoptosis. Pretreatment of mice with IFN-gamma markedly enhanced LPS-induced thymocyte apoptosis. Thymocyte apoptosis augmented by IFN-gamma occurred in the thymic cortex, and target cells undergoing apoptosis were CD4+8+ immature thymocytes. IFN-gamma itself did not induce thymocyte apoptosis in vivo and in vitro. IFN-gamma exhibited no synergistic action with effector molecules, such as tumor necrosis factor (TNF)-alpha and glucocorticoids. Further, it was shown that IFN-gamma did not enhance the susceptibility of thymocytes to apoptosis. Pretreatment of mice with IFN-gamma significantly augmented the serum TNF-alpha level and the serum cortisol level in response to LPS. Therefore, we suggest that IFN-gamma might augment LPS-induced thymocyte apoptosis through elevating serum TNF-alpha and cortisol levels.

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Citations

Mar 17, 2007·Apoptosis : an International Journal on Programmed Cell Death·Chun-Shiang ChungAlfred Ayala
Apr 28, 2004·Biochemical and Biophysical Research Communications·Weiwen JiangDavid S Pisetsky
Apr 7, 2007·Brain, Behavior, and Immunity·Ana Rosa PérezOscar A Bottasso
Mar 3, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Xuan LuoNaihan Xu
Oct 2, 2002·Shock·Colm PowerH Paul Redmond
Aug 15, 2006·The Journal of Biological Chemistry·Karim IskanderAnil K Jaiswal
Aug 28, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Margarida BorgesRui Appelberg
May 23, 2002·The Journal of Immunology : Official Journal of the American Association of Immunologists·Neru MunshiRamesh K Ganju
Dec 3, 2005·Comparative Biochemistry and Physiology. Part A, Molecular & Integrative Physiology·Brooke D Humphrey, Kirk C Klasing

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