Augmentation of murine natural killer cell activity by manganese chloride

Toxicology and Applied Pharmacology
R R RogersR J Smialowicz

Abstract

Natural killer (NK) cell activity of spleen cells from male CBA/J mice was augmented by a single parenteral injection of MnCl2 administered 1 day prior to testing by in vitro and in vivo isotope release assays. Increased cytotoxic activity was observed in vitro against both NK-sensitive (YAC-1) and NK-resistant (EL-4) target cells. NK activity was also enhanced in normally low (A/J) and intermediately (C57Bl/6J) reactive strains of mice. Augmentation of NK activity by MnCl2 was accompanied by an increase in circulating interferon (IFN) levels.

References

Mar 1, 1978·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·R J Schimmel
Jan 1, 1979·Immunological Reviews·R B HerbermanP Puccetti
Jan 1, 1974·Cancer Research·F W SundermanL J Cralley
Apr 15, 1980·International Journal of Cancer. Journal International Du Cancer·C RiccardiR B Herberman
Sep 1, 1981·The Journal of Experimental Medicine·N MinatoB R Bloom
Jan 1, 1981·Journal of Interferon Research·T SudoS Kobayashi
Mar 1, 1981·Hormone and Metabolic Research = Hormon- Und Stoffwechselforschung = Hormones Et Métabolisme·P I Rennie, J D Upton
Sep 15, 1982·International Journal of Cancer. Journal International Du Cancer·R H WiltroutH T Holden
Jan 1, 1982·Cancer Immunology, Immunotherapy : CII·D L McCollester
May 1, 1981·Biological Reviews of the Cambridge Philosophical Society·C J Sanderson
Oct 2, 1981·Science·R B Herberman, J R Ortaldo
May 15, 1981·International Journal of Cancer. Journal International Du Cancer·E Gorelik, R B Herberman

❮ Previous
Next ❯

Citations

Aug 1, 1987·Biological Trace Element Research·K S KasprzakL A Poirier
Jan 1, 1988·Developmental and Comparative Immunology·M Cossarini-DunierV Guerin
Feb 1, 1987·Immunopharmacology·R W LuebkeR J Smialowicz
Jan 1, 1986·Journal of Toxicology and Environmental Health·R W LuebkeR J Smialowicz
Jan 1, 1986·Journal of Toxicology and Environmental Health·R J SmialowiczR W Luebke
Jan 1, 1987·Journal of Toxicology and Environmental Health·R J SmialowiczD G Rowe
Jan 1, 1987·Journal of Toxicology and Environmental Health·B SrisuchartR P Sharma
Jan 1, 1984·Journal of Immunopharmacology·R J SmialowiczR J Garner
Feb 1, 1985·Environmental Research·R J SmialowiczR W Luebke
Jan 1, 1988·Immunopharmacology and Immunotoxicology·R J SmialowiczG R Burleson

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cancer Biology: Molecular Imaging

Molecular imaging enables noninvasive imaging of key molecules that are crucial to tumor biology. Discover the latest research in molecular imaging in cancer biology in this feed.