Augmentation of signal transducer and activation of transcription (STAT)6 and STAT3 expression in stimulated B and T cells

Biochemical and Biophysical Research Communications
Y ArinobuK Izuhara

Abstract

Signal transducer and activation of transcription (STAT)6 has a central role in the signal transduction of interleukin (IL)-4 and IL-13. It has recently been revealed that STAT3 is also involved. STAT6 and STAT3 are expressed ubiquitously; however, it remains unknown how STAT6 and STAT3 expression is regulated. In this study, we found that STAT6 expression was augmented at the transcription level in B and T cells stimulated with anti-IgM antibody and anti-CD40 antibody or PMA and ionomycin, respectively, and that STAT3 expression was similarly augmented in the stimulated B cells. The stimulated B and T cells showed enhancement of STAT6 activation and CD23 expression induced by IL-4 and IL-13. Augmentation of STAT6 and STAT3 would be a mechanism of the amplification of the IL-4 and IL-13 signals in stimulated B and T cells.

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Citations

May 23, 2003·Infection and Immunity·Jeffrey A GoldMichael D Weiden
Apr 24, 2004·American Journal of Respiratory Cell and Molecular Biology·Rana NagarkattiBalaram Ghosh
Feb 13, 2002·The American Journal of Pathology·Kate BleaseCory M Hogaboam
Jan 29, 2017·Molecular Cancer Research : MCR·Uri RozovskiZeev Estrov

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