PMID: 6977616Apr 1, 1982Paper

Augmentation of the anti-tumor therapeutic efficacy of long-term cultured T lymphocytes by in vivo administration of purified interleukin 2

The Journal of Experimental Medicine
M A CheeverS Gillis

Abstract

Spleen cells from C57BL/6 mice immunized in vivo with a syngeneic Friend virus-induced leukemia, FBL-3, were specifically activated by culture for 7 d with FBL-3, then nonspecifically induced to proliferate in vitro for 12 d by addition of supernatants from concanavalin A-stimulated lymphocytes containing interleukin 2 (IL-2). Such long-term cultured T lymphocytes have previously been shown to specifically lyse FBL-3 and to mediate specific adoptive therapy of advanced disseminated FBL-3 when used as an adjunct to cyclophosphamide (CY) in adoptive chemoimmunotherapy. Because the cultured cells are dependent upon IL-2 for proliferation and survival in vitro, their efficacy in vivo is potentially limited by the availability of endogenous IL-2. Thus, the aim of the current study was to determine whether exogenously administered purified IL-2 could augment the in vivo efficacy of long-term cultured T lymphocytes. Purified IL-2 alone or as an adjunct to CY as ineffective in tumor therapy. However, IL-2 was extremely effective in augmenting the efficacy of IL-2-dependent long-term cultured T lymphocytes in adoptive chemoimmunotherapy. The mechanism by which IL-2 functions in vivo is presumably by promoting in vivo growth and/or survi...Continue Reading

References

Dec 1, 1979·The Journal of Experimental Medicine·J Watson
Jul 14, 1977·Nature·S Gillis, K A Smith
Jan 1, 1979·Annals of the New York Academy of Sciences·K A SmithF W Ruscetti
Jan 1, 1976·Annals of the New York Academy of Sciences·H FriedmanJ Kateley
Jan 11, 1976·Annals of the New York Academy of Sciences·A FeferJ R Berenson
Jan 1, 1980·Journal of Immunological Methods·D Y MochizukiS Gillis

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Citations

Apr 1, 1996·Cancer·J BrittendenO Eremin
Nov 1, 1991·International Journal of Cell Cloning·R S SelvanM Nagarkatti
May 1, 1993·Stem Cells·H Zwierzina
Oct 15, 1985·Cellular Immunology·J W HootonV Paetkau
Jan 1, 1984·Disease-a-month : DM·J Laurence
Nov 16, 1984·Journal of Immunological Methods·L O Gehman, R J Robb
Apr 22, 1985·Journal of Immunological Methods·T NishimuraY Hashimoto
Jan 1, 1984·Veterinary Immunology and Immunopathology·L C GasbarreR D Romanowski
Sep 1, 1986·Veterinary Immunology and Immunopathology·J L StottB I Osburn
Oct 1, 1988·Veterinary Immunology and Immunopathology·R M Bauer, R G Olsen
Jan 1, 1985·International Journal of Immunopharmacology·V J Merluzzi, K Last-Barney
Jan 1, 1990·International Journal of Immunopharmacology·B S SharmaR K Robins
Jan 1, 1990·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·S N BykovskayaN V Malachova
Apr 1, 1996·Critical Reviews in Oncology/hematology·A E Chang, S Shu
Jun 22, 2001·Critical Reviews in Oncology/hematology·R L HayesC Zaroulis
Sep 3, 2003·Nature Reviews. Cancer·Mark E Dudley, Steven A Rosenberg
Sep 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M O DaileyI L Weissman
Feb 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A S SternS Gillis
Apr 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A AltmanA N Theofilopoulos
Mar 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·N UtsunomiyaM Nakanishi
Oct 1, 1982·The Journal of Experimental Medicine·H D EngersG D Sorenson
Oct 1, 1990·The Journal of Experimental Medicine·B GansbacherE Gilboa
Jun 1, 1997·Immunological Reviews·M A Cheever, W Chen
Nov 20, 2002·The Journal of Clinical Investigation·William Y HoPhilip D Greenberg
Jun 6, 2007·The Journal of Clinical Investigation·Carl H June
Mar 11, 2009·Journal of Biomedical Science·Pablo MatarGuillermo Mazzolini
Mar 1, 1986·Journal of Neuroimmunology·H J Schluesener, H Lassmann

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