Augmentation of wound healing by ascorbic acid treatment in mice exposed to gamma-radiation

International Journal of Radiation Biology
Ganesh Chandra JagetiaP Kumar

Abstract

Because of the crucial practical importance of acute radiation exposure associated with combined injuries, the study was undertaken to investigate the effect of various doses of ascorbic acid on the survival and healing of wounds in mice exposed to whole-body gamma-radiation. Animals were given double-distilled water or different doses of ascorbic acid by intraperitoneal injection before exposure to 0 or 10 Gy whole-body gamma-radiation to evaluate the effect of ascorbic acid on radiation-induced mortality. The animals were monitored daily for the symptoms of radiation sickness and mortality. In a separate experiment, animals were administered with either double-distilled water or different doses of ascorbic acid before exposure to 0 or 6 Gy whole-body gamma-radiation to investigate the effect of ascorbic acid on the irradiated wound. A full-thickness skin wound was created on the dorsum of the irradiated mice and the progression of wound contraction was monitored by capturing video images of the wound at various post-irradiation periods. Treatment of mice with various doses of ascorbic acid elevated survival of mice and a highest number of survivors (67 and 33% for 10 and 30 days post-irradiation) was observed for 250 mg kg(-1...Continue Reading

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Citations

Oct 2, 2008·Reproduction : the Official Journal of the Society for the Study of Fertility·Hossein Mozdarani, Elmina Nazari
Sep 3, 2011·International Wound Journal·Ganesh Chandra Jagetia, Golgod Krishnamurthy Rajanikant
Nov 15, 2008·Acta histochemica·Mehmet Kanter, Meryem Akpolat
Jan 16, 2007·Burns : Journal of the International Society for Burn Injuries·Ganesh Chandra JagetiaK V N Mallikarjun Rao
Sep 17, 2011·The International Journal of Lower Extremity Wounds·Chunmeng Shi, Shuliang Lu
Apr 14, 2005·Nutrition Reviews·Maria Valeria CataniLuciana Avigliano
Jul 8, 2021·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·Julie GlowackiJoel S Greenberger

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