Augmented B lymphocyte response to antigen in the absence of antigen-induced B lymphocyte signaling in an IgG-transgenic mouse line.

PloS One
Rong-Yong ManTakeshi Tsubata

Abstract

IgG-containing B cell antigen receptor (IgG-BCR), the BCR mostly expressed on memory B cells, contains a distinct signaling function from IgM-BCR or IgD-BCR expressed on naïve B cells. Because naïve B cells transgenic for IgG exhibit augmented response to antigens similar to memory B cells, the distinct signaling function of IgG-BCR appears to play a role in augmented antibody responses of memory B cells. However, how IgG-BCR signaling augments B cell responses is not yet well understood. Here we demonstrate that B cells from IgG-transgenic mice are anergic with defect in generation of BCR signaling upon BCR ligation. However, these IgG-transgenic B cells generate markedly augmented antibody response to a T cell-dependent antigen, probably due to hyper-responsiveness to a T cell-derived signal through CD40. Both BCR signaling defect and augmented response to CD40 ligation are partially restored in xid IgG-transgenic mice in which BCR signaling is down-modulated due to a loss-of-function mutation in the tyrosine kinase Btk crucial for BCR signaling. Thus, IgG-BCR induces augmented B cell responses in the absence of antigen-induced BCR signaling probably through high ligand-independent BCR signaling that may "idle" B cells to mak...Continue Reading

References

Jan 1, 1992·Annual Review of Immunology·M Reth
Oct 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·A OchiN Hozumi
Nov 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·R J NoelleE S Vitetta
Jan 1, 1995·Annual Review of Immunology·J J MondC M Snapper
Jan 1, 1996·European Journal of Immunology·M BattegayH Eibel
Jun 14, 1996·Science·M CascalhoM Wabl
Nov 1, 1996·Science·T L O'KeefeM S Neuberger
Feb 1, 1997·Current Biology : CB·L NitschkeM C Lamers
Aug 1, 1997·Current Opinion in Immunology·S Desiderio
Aug 5, 1998·Proceedings of the National Academy of Sciences of the United States of America·A V Gett, P D Hodgkin
Oct 30, 1999·European Journal of Immunology·A MakowskaS Cardell
Mar 3, 2001·Current Opinion in Immunology·F Martin, J F Kearney
Jan 24, 2002·The Journal of Experimental Medicine·Yijin LiMartin Weigert
Jan 29, 2002·Nature Immunology·Stephen W Martin, Christopher C Goodnow
May 30, 2002·Nature Reviews. Immunology·Flavius Martin, John F Kearney
Dec 4, 2002·Nature Reviews. Immunology·Hiroaki Niiro, Edward A Clark
Dec 21, 2002·Science·Chisato WakabayashiTakeshi Tsubata
Mar 20, 2004·Scandinavian Journal of Immunology·C HaaseT N Jørgensen
May 12, 2004·Current Opinion in Immunology·John G Monroe
Mar 18, 2005·Annual Review of Immunology·Shiv PillaiStewart T Moran
Oct 4, 2005·Nature Immunology·Stephen B GauldJohn C Cambier
Mar 25, 2006·Nature Reviews. Immunology·John G Monroe
Apr 18, 2006·Current Opinion in Immunology·Stephen B GauldJohn C Cambier
Dec 19, 2006·Immunity·Kevin T MerrellJohn C Cambier
Apr 11, 2007·The Journal of Experimental Medicine·Keisuke HorikawaChristopher C Goodnow
Jul 21, 2007·Nature Reviews. Immunology·John C CambierBarbara J Vilen

❮ Previous
Next ❯

Citations

Dec 10, 2016·ELife·Zhiyong YangChristopher D C Allen
Apr 15, 2011·The Journal of Immunology : Official Journal of the American Association of Immunologists·Kei HaniudaDaisuke Kitamura
Oct 9, 2018·Frontiers in Immunology·Eric E Irons, Joseph T Y Lau

❮ Previous
Next ❯

Methods Mentioned

BETA
transgenic
flow cytometry
ELISA

Software Mentioned

CELLQuestâ¢

Related Concepts

Related Feeds

B cells: Gene Expression

B lymphocytes are white blood cells that play a role in the adaptive immune system by secreting antibodies. Here is the latest research on gene expression in B cells.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Bioinformatics in Biomedicine

Bioinformatics in biomedicine incorporates computer science, biology, chemistry, medicine, mathematics and statistics. Discover the latest research on bioinformatics in biomedicine here.

Birth Defects

Birth defects encompass structural and functional alterations that occur during embryonic or fetal development and are present since birth. The cause may be genetic, environmental or unknown and can result in physical and/or mental impairment. Here is the latest research on birth defects.

B cell Differentiation

Depending on the signal received through the B cell receptor and other receptors, B cells differentiate into follicular or marginal zone B cells. Here is the latest research pertaining to this differentiation process.