Augmented endothelium-dependent contraction to angiotensin II in the SHR aorta: role of an inducible cyclooxygenase metabolite

Journal of Cardiovascular Pharmacology
A ZerroukP E Chabrier

Abstract

The purpose of this study was to investigate the mechanisms involved in the angiotensin II-induced increase in the contractile response of the hypertensive wall after prolonged incubation in the organ-bath buffer. In 5-h incubated rings, the contractile response to angiotensin II in aortic rings with endothelium from spontaneously hypertensive rats (SHRs) was markedly exaggerated in comparison to 2-h incubated rings. No such potentiation was observed in SHR rings after removal of the endothelium or in intact and denuded Wistar-Kyoto (WKY) rat rings. Aspirin and SQ29548 inhibited and cycloheximide and actinomycin D reduced the time-dependent enhanced response to angiotensin II in rings with endothelium from SHRs. In SHR rings with endothelium incubated for 2 h, the contractions caused by angiotensin II were potently inhibited by piroxicam but were unaffected by NS-398. Conversely, in rings incubated for 5 h, the hyperresponsiveness to angiotensin II was inhibited to a greater extent by NS-398 than by piroxicam. Piroxicam but not NS-398 had a further inhibitory effect on the residual angiotensin II-induced contraction in actinomycin D-treated rings incubated for 5 h. In conclusion, our study shows that long-term incubation leads ...Continue Reading

References

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Citations

Mar 25, 2010·Pflügers Archiv : European journal of physiology·Michel FélétouPaul M Vanhoutte
Feb 18, 2009·Acta Physiologica·P M VanhoutteM Feletou
Nov 24, 2004·Clinical and Experimental Hypertension : CHE·Gabrielle GendronDomenico Regoli
Aug 28, 2003·Clinical and Experimental Hypertension : CHE·Mahmoud M El-MasS Jamal Mustafa
Sep 27, 2008·The Journal of Physiology·Paul M Vanhoutte, Eva H C Tang
Jan 22, 2009·British Journal of Pharmacology·Michel FélétouPaul M Vanhoutte
Sep 6, 2005·European Journal of Pharmacology·Susana JerezAlfredo Coviello
Dec 27, 2015·Acta Physiologica·P M VanhoutteE H C Tang
Nov 2, 2004·Journal of Applied Physiology·Candice D FikeSandra L Pfister
Jul 1, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hongwei LiColin Sumners
Jan 25, 2007·The Journal of Pharmacology and Experimental Therapeutics·Yolanda AlvarezMercedes Salaices
Apr 19, 2005·Journal of Hypertension·Ayotunde S O AdeagboMabayoje A Oriowo
Aug 20, 2019·Basic & Clinical Pharmacology & Toxicology·Katrina M Mirabito ColafellaJorie Versmissen

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