Augmented intestinal trefoil factor (TFF3) and loss of pS2 (TFF1) expression precedes metaplastic differentiation of gastric epithelium

Laboratory Investigation; a Journal of Technical Methods and Pathology
D TaupinA Giraud

Abstract

The trefoil peptides spasmolytic polypeptide (SP), intestinal trefoil factor (ITF), and pS2 show lineage-specific expression in the normal gut and are strongly induced after mucosal injury. We assessed the relationship between this induction and the development of the regenerative epithelial lineage over time in the rat stomach and verified these observations in the metaplastic and dysplastic human stomach. Antral or colonic ulcers were induced in Wistar rats by application of serosal acetic acid and tissues harvested 2 hours to 125 days later. Human endoscopic biopsies or gastric resection specimens were also assessed. Tissues were examined by radioimmunoassay, immunoblotting, or immunohistochemistry for ITF, SP, and transforming growth factor alpha (rat) or ITF and pS2 (human) expression. ITF and SP mRNA in antral ulcer margins was localized by in situ hybridization. ITF and SP peptide expression rose steadily in ulcer margins after 4 days, with the rise in ITF being more pronounced. By 40 days, several hundred-fold elevations in ITF levels were present, with a field effect in uninvolved mucosa. Hyperproliferative, elongated glands of undifferentiated cells expressing abundant trefoil peptides and acid sulfomucins were presen...Continue Reading

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Citations

Sep 25, 2003·Nature Reviews. Molecular Cell Biology·Douglas Taupin, Daniel K Podolsky
Oct 18, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Motoko SasakiYasuni Nakanuma
Oct 18, 2003·Laboratory Investigation; a Journal of Technical Methods and Pathology·Barbara M AldermanAndrew S Giraud
Feb 9, 2013·Scandinavian Journal of Clinical and Laboratory Investigation·Mie Hessellund Samson
Aug 21, 2013·Clinical Oral Investigations·Ponlatham ChaiyaritAndrew S Giraud
Aug 25, 2018·Experimental & Molecular Medicine·Jieying LiuYeun-Jun Chung
Jul 11, 2003·World Journal of Gastroenterology : WJG·Bao-Ping YuJie-Ping Yu
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