Augmented levels of CD44 in macrophages from atherosclerotic subjects: a possible IL-6-CD44 feedback loop?

Atherosclerosis
Daniel A HäggAlexandra Krettek

Abstract

The cell-adhesion molecule CD44 likely participates in atherosclerosis development. We have shown previously that pro-inflammatory cytokines affect CD44 expression. Therefore, this work examined the role of elevated CD44 levels in human macrophages. Macrophages from human atherosclerotic subjects (n=15) showed elevated levels of CD44 transcript and protein (1.5-fold) compared to matched controls (n=15) (P=0.050 and 0.044, respectively). To test whether genetic factors influence CD44 expression, two single nucleotide polymorphisms in the CD44 gene were analyzed but these were not associated with coronary artery disease. We also examined the potential connection between plasma cytokine levels and CD44 expression. In atherosclerotic subjects, elevated CD44 expression correlates (P=0.012) with enhanced macrophage IL-6 secretion (3.13+/-2.5 pg/mL versus 0.32+/-0.16 pg/mL in controls, P=0.021). Additionally, CD44-deficient mice exhibit less circulating IL-6 than wild-type controls (9.8+/-0.7 pg/mL versus 14.3+/-0.7 pg/mL; P=0.032). Furthermore, IL-6 augments CD44 expression in primary human macrophages after 24 h (P=0.038) and 48 h (P=0.015). Taken together, our data show an IL-6-CD44 feedback loop in macrophages. Such a positive fee...Continue Reading

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Citations

Jan 10, 2012·Inflammation Research : Official Journal of the European Histamine Research Society ... [et Al.]·Koon-Yeow LeowChew-Kiat Heng
Apr 10, 2013·Pharmaceutical Research·Mohammad H El-DakdoukiXuefei Huang
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Apr 22, 2015·Biomaterials·Ga Young LeeIn-San Kim
Jan 1, 2008·Proteomics. Clinical Applications·Angus BrownCristobal Dos Remedios
Feb 12, 2017·International Journal of Epidemiology·Kirsten MehligLauren Lissner
Aug 3, 2021·Mediators of Inflammation·Kinga JaskułaDominik S Skiba

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