Augmented sympathetic tone alters muscle metabolism with exercise: lack of evidence for functional sympatholysis

Journal of Applied Physiology
J Kevin ShoemakerL I Sinoway

Abstract

It is unclear whether sympathetic tone opposes dilator influences in exercising skeletal muscle. We examined high levels of sympathetic tone, evoked by lower body negative pressure (LBNP, -60 mmHg) on intramuscular pH and phosphocreatine (PCr) levels (31P-nuclear magnetic resonance spectroscopy) during graded rhythmic handgrip (30 contractions/min; approximately 17, 34, 52 and 69% maximal voluntary contraction). Exercise was performed with LBNP and without LBNP (Control). At the end of exercise, LBNP caused lower levels of muscle pH (6.59 +/- 0.09) compared with Control (6.78 +/- 0.05; P < 0.05). PCr recovery, an index of mitochondrial respiration, was less during the recovery phase of the LBNP trial. Exercise mean arterial pressure was not altered by LBNP. The protocols were repeated with measurements of forearm blood flow velocity and deep venous samples (active forearm) of hemoglobin (Hb) saturation, pH, and lactate. With LBNP, mean blood velocity was reduced at rest, during exercise, and during recovery compared with Control (P < 0.05). Also, venous Hb saturation and pH levels during exercise and recovery were lower with LBNP and lactate was higher compared with Control (P < 0.05). We conclude that LBNP enhanced sympathetic...Continue Reading

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Citations

Jun 6, 1998·Journal of Applied Physiology·J K ShoemakerL I Sinoway
Nov 6, 1998·Journal of Applied Physiology·J K ShoemakerL I Sinoway
Aug 3, 2000·American Journal of Physiology. Heart and Circulatory Physiology·F LeeL I Sinoway
Jul 13, 2004·Journal of Applied Physiology·Gail D Thomas, Steven S Segal
Nov 17, 2007·Clinical Physiology and Functional Imaging·Marc CharlesFrédéric Costes
Feb 13, 2001·American Journal of Physiology. Heart and Circulatory Physiology·H L CollinsD S O'Leary
Aug 25, 2010·The Journal of Pharmacology and Experimental Therapeutics·Gary J HodgesRoss D Feldman
Oct 13, 2007·Heart Failure Reviews·Carlos Eduardo Negrao, Holly R Middlekauff
Feb 2, 2016·COPD·Helge HaarmannTobias Raupach
Jul 2, 2003·Journal of Applied Physiology·Joseph C DaleyLawrence I Sinoway
Jun 19, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Jong-Kyung KimDonal S O'Leary
Oct 13, 2007·Journal of Applied Physiology·Joaquin U GonzalesBarry W Scheuermann
Apr 16, 2014·Scandinavian Journal of Medicine & Science in Sports·T C BarbosaB M Silva
May 8, 1999·The American Journal of Physiology·J K ShoemakerL I Sinoway
Jan 14, 2003·Journal of Applied Physiology·M E Tschakovsky, R L Hughson
Jul 23, 2005·Journal of Applied Physiology·Lawrence I Sinoway, Jianhua Li

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