PMID: 8983868Oct 1, 1996Paper

Augmented thermic effect of amino acids under general anaesthesia occurs predominantly in extra-splanchnic tissues

Clinical Science
E SelldénT Brundin

Abstract

1. Intravenous infusion of amino acid mixtures stimulates human oxidative heat production more effectively under general anaesthesia than in the unanaesthetized state. To analyse the splanchnic and extra-splanchnic regional distribution of this stimulation, whole body and splanchnic oxygen uptake, blood flow and blood temperatures were measured by a catheterization technique in 14 patients undergoing isoflurane anaesthesia for abdominal surgery. During the anaesthesia period, a mixture of 19 amino acids (240 kJ/h) was infused intravenously into seven of the patients while the others served as controls, receiving isovolumic infusions of a nutrient-free saline solution. 2. Whole body oxygen consumption fell by approximately 40% during anaesthesia and surgery in the controls. Approximately 80-95% of the reduction occurred in the extra-splanchnic tissues. The splanchnic oxygen uptake fell by 31 +/- 6% in the controls during the initial phase of anaesthesia, after which it returned to the pre-anaesthesia level. The initial reduction of the controls' splanchnic oxygen consumption accounted for only approximately 23% of the simultaneous anaesthesia-induced reduction in pulmonary oxygen uptake. No initial reduction of the splanchnic ox...Continue Reading

Citations

May 25, 2010·Journal of Nutritional Science and Vitaminology·Akinobu ImotoEva Selldén
May 25, 2010·Journal of Nutritional Science and Vitaminology·Masahiro KanazawaToshiyasu Suzuki
Apr 28, 2004·Anesthesiology·Yasufumi NakajimaToshiki Mizobe
Aug 1, 2013·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Ayse B OzerÖmer L Erhan
Dec 15, 2005·American Journal of Physiology. Endocrinology and Metabolism·Ippei YamaokaFumiaki Yoshizawa
May 30, 2006·Anesthesiology·Sten Lindahl
Oct 3, 2006·Current Opinion in Anaesthesiology·A J Davis, B Bissonnette
Oct 10, 1997·Anesthesia and Analgesia·R E Shangraw, S T Robinson
Sep 5, 1998·Anesthesia and Analgesia·E Selldén, S G Lindahl
Apr 1, 1997·Anesthesiology·S G Lindahl
Sep 26, 2002·The Proceedings of the Nutrition Society·Eva Selldén
Nov 23, 2016·The Cochrane Database of Systematic Reviews·Sheryl WarttigAndrew F Smith
Feb 26, 2000·Anesthesiology·D I Sessler
Aug 17, 2001·Anesthesiology·D I Sessler
Jul 14, 2012·Journal of Nutritional Science and Vitaminology·Satoko AndoToshiyasu Suzuki

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