Augmenting exercise capacity with noninvasive ventilation in high-level spinal cord injury

Journal of Applied Physiology
James W MorganIsabelle Vivodtzev

Abstract

High-level spinal cord injury (SCI) results in a very limited innervated skeletal muscle mass that strongly reduces exercise capacity. Our recent work showed that when adding functional electrical stimulation (FES) of the paralyzed legs (hybrid FES-exercise) to produce higher exercise capacity, peak ventilation became a limiting factor to training-induced improvement in aerobic capacity. Our assumption was that the systemic adaptations to exercise training are delimited by the maximal ventilation that can be achieved. However, herein, we present a case showing an acute increase in aerobic capacity when using noninvasive ventilatory support (NIV) during FES-rowing test in an individual who had previously experimented a plateau in his aerobic capacity for 18 mo. An 18-yr-old man with C5 SCI trained with arms-only rowing for 6 mo and subsequently trained with hybrid FES-rowing for 18 mo. Peak minute ventilation (V̇epeak) and peak oxygen consumption (V̇o2peak) were increased after arms-only training and increased further with 6 mo of hybrid FES-row training. Despite continued intense and frequent, hybrid FES-row training, neither V̇epeak nor V̇o2peak increased further over the next year (1.94 and 66.0 l/min). However, when this ind...Continue Reading

References

Sep 1, 1992·Journal of Applied Physiology·B D JohnsonJ A Dempsey
Jul 25, 2000·Journal of Applied Physiology·C A HarmsJ A Dempsey
Feb 13, 2002·The Journal of Orthopaedic and Sports Physical Therapy·Richard K Shields
Oct 13, 2009·Respiration; International Review of Thoracic Diseases·Michael DreherWolfram Windisch
Oct 31, 2009·Journal of Applied Physiology·Cheryl M SalomeNorbert Berend
Jul 2, 2011·Medicine and Science in Sports and Exercise·Christopher R WestLee M Romer
Sep 29, 2011·PM & R : the Journal of Injury, Function, and Rehabilitation·J Andrew TaylorJeffrey J Widrick
Nov 2, 2011·Respirology : Official Journal of the Asian Pacific Society of Respirology·Stephen W Littleton
Jan 9, 2014·American Journal of Physical Medicine & Rehabilitation·Maya BattikhaJ Andrew Taylor
Jan 20, 2016·Medicine and Science in Sports and Exercise·Shuang QiuJ Andrew Taylor

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Citations

Dec 23, 2020·Journal of Cardiopulmonary Rehabilitation and Prevention·Isabelle Vivodtzev, J Andrew Taylor

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Clinical Trials Mentioned

NCT02139436
NCT02865343

Software Mentioned

ExPD

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