AUR Memorial Award. Identification of myocardial cell death in reperfused myocardial injury using dual mechanisms of contrast-enhanced magnetic resonance imaging

Academic Radiology
J F GeschwindC B Higgins

Abstract

Because the magnitude of dysprosium-induced signal loss depends on the microheterogeneity of its distribution (exclusion from intracellular space), we proposed that loss of myocardial cell integrity would be reflected by decreased potency of dysprosium in the injured compared with normal myocardium. We measured the effect of dysprosium on magnetic resonance (MR) imaging signal intensity of reperfused infarcted and nonischemic myocardium and related it to tissue concentration of the contrast media. Rats were subjected to 1 hr coronary artery occlusion followed by 1 hr reperfusion. After 45 min of reflow, group 1 (n = 9) received 1.0 and 0.2 mmol/kg dysprosium diethylenetriamine pentaacetic acid-bismethylamide (Dy-DTPA-BMA) and gadodiamide (Gd-DTPA-BMA), respectively. Group 2 (n = 7) received no contrast agents. Excised hearts were imaged with spin-echo T1- and T2-weighted sequences. After imaging, hearts were stained (triphenyltetrazolium chloride) to define the injured zones. Concentrations of Dy-DTPA-BMA and Gd-DPTA-BMA in regional myocardial tissue were determined by induction coupled plasma-atomic emission spectrometry. Separate groups received one or the other contrast medium alone to control for potential error from the mi...Continue Reading

References

Jan 1, 1993·Acta Radiologica·M WikströmA Hemmingsson
Jan 1, 1993·Journal of Magnetic Resonance Imaging : JMRI·S M Rocklage, A D Watson

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Citations

May 20, 1999·Journal of Magnetic Resonance Imaging : JMRI·C ArteagaE Canet
Nov 5, 1999·Journal of Magnetic Resonance Imaging : JMRI·M F WendlandC B Higgins
Aug 6, 2000·European Journal of Radiology·M SaeedC B Higgins
Oct 21, 2011·Radiology·Karen G Ordovas, Charles B Higgins
Mar 1, 1997·Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine·M F WendlandC B Higgins
Feb 17, 1999·Circulation·C B Higgins
Jun 8, 2001·Experimental Biology and Medicine·M Saeed
May 24, 2011·Progress in Nuclear Magnetic Resonance Spectroscopy·Małgorzata Norek, Joop A Peters

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