Auranofin, an immunosuppressive drug, inhibits MHC class I and MHC class II pathways of antigen presentation in dendritic cells

Archives of Pharmacal Research
Shinha HanKyungjae Kim

Abstract

Auranofin (AF), an orally administered, gold-based, anti-arthritic agent, has emerged as a clinically useful therapeutic drug for the treatment of rheumatoid arthritis. In the present study, we examined the effects of AF on major histocompatibility complex (MHC)-restricted antigen presentation in dendritic cells (DCs), which are the most important accessory cells for the induction of T cell responses. A mouse dendritic cell line, DC2.4 cells, and DCs that were generated from mouse bone marrow cells by culturing with granulocyte macrophage-colony stimulating factor (GM-CSF) and interleukin (IL)-4 were each pretreated with AF for 2 hr, and then incubated with ovalbumin (OVA). After the 2-hr incubation, the DCs were fixed, and the amounts of OVA peptide-H-2Kb complexes were assessed using OVa-specific CD8+ T cells. AF inhibited MHC class I-restricted presentation of exogenous OVA. This inhibitory activity of AF appeared to be due not only to the inhibition of the phagocytic activity of DCs, but also to the suppression of MHC molecule expression on DCs. AF also inhibited MHC class II-restricted presentation of exogenous OVA. These results show that AF exerts immunosuppressive activity at least in part by inhibiting MHC-restricted a...Continue Reading

References

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Citations

Mar 5, 2016·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Xing LiErwei Sun
Aug 30, 2012·Dalton Transactions : an International Journal of Inorganic Chemistry·Declan Gaynor, Darren M Griffith
Jul 23, 2020·Frontiers in Chemistry·Shuang YueShuang Wei
Feb 26, 2021·Scientific Reports·Sinead M O'DonovanRobert E McCullumsmith
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger
Dec 29, 2021·Immunological Medicine·Rafael Cardoso Maciel Costa SilvaBruno Ricardo Barreto Pires

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