Auranofin-loaded nanoparticles as a new therapeutic tool to fight streptococcal infections

Scientific Reports
Roberto Díez-MartínezPedro García

Abstract

Drug-loaded nanoparticles (NPs) can improve infection treatment by ensuring drug concentration at the right place within the therapeutic window. Poly(lactic-co-glycolic acid) (PLGA) NPs are able to enhance drug localization in target site and to sustainably release the entrapped molecule, reducing the secondary effects caused by systemic antibiotic administration. We have loaded auranofin, a gold compound traditionally used for treatment of rheumatoid arthritis, into PLGA NPs and their efficiency as antibacterial agent against two Gram-positive pathogens, Streptococcus pneumoniae and Streptococcus pyogenes was evaluated. Auranofin-PLGA NPs showed a strong bactericidal effect as cultures of multiresistant pneumococcal strains were practically sterilized after 6 h of treatment with such auranofin-NPs at 0.25 μM. Moreover, this potent bactericidal effect was also observed in S. pneumoniae and S. pyogenes biofilms, where the same concentration of auranofin-NPs was capable of decreasing the bacterial population about 4 logs more than free auranofin. These results were validated using a zebrafish embryo model demonstrating that treatment with auranofin loaded into NPs achieved a noticeable survival against pneumococcal infections. Al...Continue Reading

References

Jun 6, 2000·Advanced Drug Delivery Reviews·M S Shive, J M Anderson
Sep 7, 2001·Journal of Bacteriology·J HoskinsJ I Glass
Dec 26, 2001·Chemical Reviews·C F Shaw III
Feb 21, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·K AvgoustakisD S Ithakissios
Aug 10, 2002·The European Respiratory Journal. Supplement·K P Klugman
Oct 5, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Cristina FonsecaRogério Gaspar
Mar 12, 2003·Advanced Drug Delivery Reviews·Jayanth Panyam, Vinod Labhasetwar
Apr 22, 1960·Biochimica Et Biophysica Acta·S LACKS, R D HOTCHKISS
Jun 7, 2005·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·Jeffrey D Fuller, Donald E Low
May 6, 2006·International Journal of Pharmaceutics·Yvette MeissnerAlf Lamprecht
Oct 20, 2006·Journal of Nanoscience and Nanotechnology·C LecarozM J Blanco-Prieto
May 1, 2007·Biotechnology Progress·Hyun Jung LimJong-Sang Park
Aug 10, 2007·Nature·Curtis R Chong, David J Sullivan
Oct 16, 2007·British Journal of Clinical Pharmacology·J K Aronson
Oct 24, 2007·Journal of Pharmaceutical Sciences·Yvette Meissner, Alf Lamprecht
Jan 18, 2008·Journal of Pharmaceutical Sciences·Ales Prokop, Jeffrey M Davidson
Aug 19, 2008·Biomedical Materials·Rajeev Raghavan PillaiKenneth E Gonsalves
Jan 24, 2009·Journal of Biological Inorganic Chemistry : JBIC : a Publication of the Society of Biological Inorganic Chemistry·Sarah Jackson-RosarioWilliam Thomas Self
Sep 15, 2009·Lancet·Katherine L O'BrienUNKNOWN Hib and Pneumococcal Global Burden of Disease Study Team
Oct 28, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Himanshu GuptaGaurav Mittal
Dec 1, 2010·Acta Biomaterialia·Edurne ImbuluzquetaMaría J Blanco-Prieto
Jun 18, 2011·Expert Opinion on Drug Delivery·Katharina Ladewig
Jul 13, 2011·Antimicrobial Agents and Chemotherapy·Mirian DomenechMiriam Moscoso
Nov 30, 2011·Journal of Nanobiotechnology·Anil Mahapatro, Dinesh K Singh
Feb 23, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Fabienne DanhierVéronique Préat
May 12, 2012·Polymers·Hirenkumar K Makadia, Steven J Siegel
Sep 12, 2012·Inflammopharmacology·J M MadeiraA Klegeris
Apr 6, 2013·The Journal of Antimicrobial Chemotherapy·Yang ShenDaniel C Nelson
Sep 21, 2013·BMJ : British Medical Journal·Michael McCarthy
May 14, 2014·Biometals : an International Journal on the Role of Metal Ions in Biology, Biochemistry, and Medicine·Maria Iris CassettaLuigi Messori
Sep 4, 2014·Microbiology and Molecular Biology Reviews : MMBR·David LebeauxChristophe Beloin
Jan 16, 2015·American Journal of Respiratory and Critical Care Medicine·Brad SpellbergDavid N Gilbert
Feb 24, 2015·Drugs in R&D·Christine Roder, Melanie J Thomson
Mar 20, 2015·Current Medicinal Chemistry·Bharat Gadakh, Arthur Van Aerschot
Apr 2, 2015·Proceedings of the National Academy of Sciences of the United States of America·Michael B HarbutFeng Wang

❮ Previous
Next ❯

Citations

Sep 21, 2016·International Journal of Molecular Sciences·Shanshan LiuHuancai Lin
Nov 9, 2016·European Journal of Medicinal Chemistry·Joana Darc S ChavesMauro V de Almeida
Dec 19, 2018·Pharmaceutics·Marina Martínez-CarmonaMaría Vallet-Regí
Dec 15, 2019·Antibiotics·Abdulkader MasriRuqaiyyah Siddiqui
Aug 11, 2019·Materials·Valentina GrumezescuGabriel Socol
Jul 23, 2020·Frontiers in Chemistry·Shuang YueShuang Wei
Mar 16, 2019·Frontiers in Cellular and Infection Microbiology·Hanyang LiuAnita Shukla
Mar 27, 2021·ACS Applied Materials & Interfaces·Diana VilelaSamuel Sanchez
Aug 8, 2021·Nanomaterials·Alba Pensado-LópezFernando Torres Andón

❮ Previous
Next ❯

Methods Mentioned

BETA
nanoprecipitation
scanning electron microscopy
Dynamic Light Scattering

Software Mentioned

GraphPad
GraphPad InStat

Related Concepts

Related Feeds

Biofilm & Infectious Disease

Biofilm formation is a key virulence factor for a wide range of microorganisms that cause chronic infections.Here is the latest research on biofilm and infectious diseases.

Bacterial Pneumonia (ASM)

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Antifungals

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.

Bacterial Pneumonia

Bacterial pneumonia is a prevalent and costly infection that is a significant cause of morbidity and mortality in patients of all ages. Here is the latest research.

Biofilms

Biofilms are adherent bacterial communities embedded in a polymer matrix and can cause persistent human infections that are highly resistant to antibiotics. Discover the latest research on Biofilms here.

Antifungals (ASM)

An antifungal, also known as an antimycotic medication, is a pharmaceutical fungicide or fungistatic used to treat and prevent mycosis such as athlete's foot, ringworm, candidiasis, cryptococcal meningitis, and others. Discover the latest research on antifungals here.