Auraptene/Naringin-Rich Fruit Juice of Citrus kawachiensis (Kawachi Bankan) Prevents Ischemia-Induced Neuronal Cell Death in Mouse Brain through Anti-Inflammatory Responses

Journal of Nutritional Science and Vitaminology
Satoshi OkuyamaYoshiko Furukawa

Abstract

Cerebral ischemia/reperfusion leads to delayed neuronal cell death, resulting in brain damage. Auraptene (AUR) and naringin (NGIN), which exert neuroprotective effects in ischemic brain, are abundant in the peel of Citrus kawachiensis. Although parts of AUR/NGIN are transited from the peel to the juice during the squeezing of this fruit, these amounts in juice might be too low to exert effects. We thus prepared the AUR/NGIN-rich fruit juice of C. kawachiensis by addition of peel paste to the raw juice. The present study revealed that orally administration of the dried powder of this AUR/NGIN-rich fruit juice (2.5 g/kg/d) for 7 d to ischemic mice significantly suppressed the ischemia-induced neuronal cell death in the hippocampus, which was coincidently with the reduction of hyperactivation of microglia and astrocytes. These results suggest that AUR/NGIN-rich juice of C. kawachiensis may possess therapeutic potential for the prevention of neurodegenerative diseases via inhibition of inflammatory processes.

References

Jan 30, 2004·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Helen M Bramlett, W Dalton Dietrich
Apr 20, 2010·Future Neurology·Jonathan R WeinsteinThomas Möller
Sep 12, 2012·Molecular Medicine Reports·Ying LiuPei-bo Li
May 9, 2013·International Journal of Molecular Sciences·Satoshi OkuyamaYoshiko Furukawa
Sep 11, 2013·Bioscience, Biotechnology, and Biochemistry·Yoshiaki AmakuraTakashi Yoshida
Jun 24, 2014·Evidence-based Complementary and Alternative Medicine : ECAM·Satoshi OkuyamaYoshiko Furukawa
Nov 17, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Satoshi OkuyamaYoshiko Furukawa
Apr 26, 2016·Biomedical Research·Mitsunari NakajimaYoshiko Furukawa
Dec 21, 2016·Proceedings of the National Academy of Sciences of the United States of America·Minshu LiJunwei Hao

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Citations

Mar 7, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Yoshiko FurukawaMitsunari Nakajima
Jan 8, 2020·International Journal of Molecular Sciences·Yoshiko FurukawaMitsunari Nakajima
Jan 5, 2021·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Yoshiko Furukawa
Jan 5, 2021·Chemical & Pharmaceutical Bulletin·Yoshiko FurukawaTakashi Yoshida

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